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Table 3 Support measures and pharmacological treatments administered to patients admitted for SARS-COV-2

From: Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain

 

Total patients (N = 74)

Patients with MIS-C (N = 45)

Patients without MIS-C (N = 29)

p

Support measures. n/N (%)

    

Oxygen therapy

56/74 (79.7)

36/45 (80)

20/29 (69)

0.215

HFO

26/74 (35.1)

14/45 (31.1)

12/29 (41.4)

0.379

NIV

9/74 (12.2)

2/45 (4.4)

7/29 (24.1)

0.026

MV

18/74 (24.3)

6/45 (13.3)

12/29 (41.4)

0.005

Neuromuscular blockade

12/74 (16.2)

3/45 (6.7)

9/29 (31)

0.009

Ventilation in prone position

9/74 (12.2)

1/45 (2.2)

8/29 (27.6)

0.002

V-V-ECMO

1/74 (1.4)

0/45 (0)

1/29 (3.4)

0.394

A-V-ECMO

1/74 (1.4)

1/45 (2.2)

0/29 (0)

1

NOi

3/74 (4.1)

0/45 (0)

3/29 (10.3)

0.057

CRRT

0/74 (0)

0/45 (0)

0/29 (0)

-

Transfusion of hemoderivatives

14/74 (18.9)

5/45 (11.1)

9/29 (31)

0.034

Vasoactive drugs

37/74 (50)

30/45 (66.7)

7/29 (24.1)

< 0.001

Pharmacological therapies n/N (%)

    

Antibiotic

65/74 (87,8)

42/45 (93.3)

23/29 (79.3)

0.020

Lopinavir–ritonavir

30/74 (40.5)

18/45 (40)

12/29 (41.4)

0.857

Remdesivir

5/74 (6.8)

0/45 (0)

5/29 (17.2)

0.006

Hydroxychloroquine

43/74 (58.1)

25/45 (55.6)

18/29 (62.1)

0.550

Corticosteroids

49/74 (66.2)

36/45 (80)

13/29 (44.8)

0.003

Immunoglobulins

25/74 (33.8)

23/45 (51.1)

2/29 (6.9)

< 0.001

Tocilizumab

17/74 (23)

11/45 (24.4)

6/29 (20.7)

0.871

  1. Comparison of patients with MIS-C and without MIS-C
  2. HFO high-flow rate oxygen, NIV noninvasive ventilation, MV invasive mechanical ventilation, V-V-ECMO veno-venous extracorporeal membrane oxygenation, V-A ECMO veno-arterial extracorporeal membrane oxygenation, NOi Inhaled nitric oxygen, CRRT continuous renal replacement therapy