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Table 2 Course of parameters over 10 h with estimated differences between groups

From: Individualized flow-controlled ventilation compared to best clinical practice pressure-controlled ventilation: a prospective randomized porcine study

  FCV meana PCV meana MD with 95% CIa p valuea
HR /min 84.0 79.6 4.4 (−5.0 to 13.8) 0.378
MAP mmHg 70.1 65.1 5.0 (−0.3 to 10.4) 0.093
MPAP mmHg 21.8 22.8 −1.0 (−4.8 to 2.8) 0.615
CVP mmHg 9.5 12.1 −2.6 (−6.1 to 0.9) 0.177
CI l/min/m2 5.4 5.7 −0.3 (−1.0 to 0.4) 0.410
PCWP mmHg 9.5 12.6 −3.1 (−6.5 to 0.3) 0.108
PVRI dyn s/cm5/m2 327.2 260.2 67.0 (20.9 to 113.1) 0.017*
SVRI dyn s/cm5/m2 1646.1 1353.0 293.1 (51.4 to 534.7) 0.039*
Pes cm H2O 12.3 13.9 −1.6 (−3.7 to 0.5) 0.178
VT ml/kg 8.2 7.6 0.7 (0.2 to 1.2) 0.025*
RR /min 20.1 41.5 −21.3 (−22.8 to −19.9) < 0.001***
Ppeak cm H2O 16.3 17.5 −1.2 (−3.5 to 1.2) 0.350
ΔP cm H2O 13.0 12.5 0.6 (−1.7 to 2.8) 0.638
MP J/min 5.8 22.0 −16.2 (−21.1 to − 11.4) < 0.001***
MV l/min 6.0 12.7 −6.8 (−8.2 to −5.4) < 0.001***
paCO2 Torr 40.1 44.9 −4.7 (−7.4 to −2.0) 0.006**
kPa 5.35 5.98 −0.63 (−0.99 to −0.27)  
paO2 Torr 119.8 96.6 23.2 (9.0 to 37.5) 0.010*
kPa 15.97 12.87 3.10 (1.19 to 5.00)  
PEEP FCVb PCVb   p valuec
5 cm H2O 1/6 (17%) 6/6 (100%)   0.002**
4 cm H2O 0/6 (0%) 0/6 (0%)  
3 cm H2O 5/6 (83%) 0/6 (0%)  
  1. CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, HR heart rate, MAP mean arterial pressure, MD mean difference, MP mechanical power, MPAP mean pulmonary arterial pressure, MV respiratory minute volume, paCO2 arterial partial pressure of carbon dioxide, paO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, PEEP positive end-expiratory pressure, Pes esophageal pressure, Ppeak peak pressure, PVRI pulmonary vascular resistance index, RR respiratory rate, SVRI systemic vascular resistance index, VT tidal volume, ΔP driving pressure (difference between positive end-expiratory pressure and peak pressure)
  2. aEstimated mean and median difference with CI for continuous variables retrieved from linear mixed-effects model
  3. bBinary data are presented as no./total no. (%)
  4. cAssessed by Fisher’s exact test