Table 2 Course of parameters over 10 h with estimated differences between groups
FCV meana | PCV meana | MD with 95% CIa | p valuea | ||
HR | /min | 84.0 | 79.6 | 4.4 (−5.0 to 13.8) | 0.378 |
MAP | mmHg | 70.1 | 65.1 | 5.0 (−0.3 to 10.4) | 0.093 |
MPAP | mmHg | 21.8 | 22.8 | −1.0 (−4.8 to 2.8) | 0.615 |
CVP | mmHg | 9.5 | 12.1 | −2.6 (−6.1 to 0.9) | 0.177 |
CI | l/min/m2 | 5.4 | 5.7 | −0.3 (−1.0 to 0.4) | 0.410 |
PCWP | mmHg | 9.5 | 12.6 | −3.1 (−6.5 to 0.3) | 0.108 |
PVRI | dyn s/cm5/m2 | 327.2 | 260.2 | 67.0 (20.9 to 113.1) | 0.017* |
SVRI | dyn s/cm5/m2 | 1646.1 | 1353.0 | 293.1 (51.4 to 534.7) | 0.039* |
Pes | cm H2O | 12.3 | 13.9 | −1.6 (−3.7 to 0.5) | 0.178 |
VT | ml/kg | 8.2 | 7.6 | 0.7 (0.2 to 1.2) | 0.025* |
RR | /min | 20.1 | 41.5 | −21.3 (−22.8 to −19.9) | < 0.001*** |
Ppeak | cm H2O | 16.3 | 17.5 | −1.2 (−3.5 to 1.2) | 0.350 |
ΔP | cm H2O | 13.0 | 12.5 | 0.6 (−1.7 to 2.8) | 0.638 |
MP | J/min | 5.8 | 22.0 | −16.2 (−21.1 to − 11.4) | < 0.001*** |
MV | l/min | 6.0 | 12.7 | −6.8 (−8.2 to −5.4) | < 0.001*** |
paCO2 | Torr | 40.1 | 44.9 | −4.7 (−7.4 to −2.0) | 0.006** |
kPa | 5.35 | 5.98 | −0.63 (−0.99 to −0.27) | ||
paO2 | Torr | 119.8 | 96.6 | 23.2 (9.0 to 37.5) | 0.010* |
kPa | 15.97 | 12.87 | 3.10 (1.19 to 5.00) | ||
PEEP | FCVb | PCVb | p valuec | ||
5 | cm H2O | 1/6 (17%) | 6/6 (100%) | 0.002** | |
4 | cm H2O | 0/6 (0%) | 0/6 (0%) | – | |
3 | cm H2O | 5/6 (83%) | 0/6 (0%) | – | |