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Table 1 Characteristics of laboratory animals before the start of the experiment

From: Individualized flow-controlled ventilation compared to best clinical practice pressure-controlled ventilation: a prospective randomized porcine study

 

Total (n = 12)

FCV (n = 6)

PCV (n = 6)

MD with 95% CIa

p valueb

Demographic data

 Weight

kg

37.8 (33.8–43.3)

36.2 (32.9–38.7)

40.5 (36.6–44.8)

− 4.1 (− 11.6 to 2.3)

0.240

 Size

m

1.08 (1.07–1.10)

1.08 (1.06–1.10)

1.08 (1.07–1.14)

−0.03 (− 0.09 to 0.03)

0.511

 Gender

female

7/12 (58.3%)

4/6 (66.7%)

3/6 (50%)

0.53 (0.03 to 8.30)

1

Monitoring data

 HR

/min

89.0 (81.0–95.5)

91.0 (84.0–94.3)

85.0 (76.8–94.8)

3.9 (−8.0 to 20.0)

0.521

 MAP

mm Hg

65.5 (63.0–72.0)

73.0 (66.5–75.75)

63.0 (63.0–65.3)

8.0 (−4.0 to 15.0)

0.106

 MPAP

mm Hg

22.0 (20.0–23.3)

21.0 (20.3–24.8)

23.0 (20.8–23.0)

−0.5 (−4.0 to 8.0)

1

 CVP

mm Hg

10.0 (8.0–13.0)

9.0 (8.0–10.0)

13.0 (10.8–13.0)

−3.0 (−6.0 to 6.0)

0.220

 CI

l/min/m2

6.1 (5.7–6.6)

6.0 (5.6–6.4)

6.2 (5.9–7.5)

−0.4 (− 2.2 to 0.7)

0.485

 PCWP

mmHg

11.0 (9.0–13.0)

10.0 (6.0–11.0)

12.5 (11.3–13.0)

−3.0 (−8.0 to 2.0)

0.195

VT

ml/kg

7.1 (7.1–7.5)

7.2 (7.1–7.7)

7.1 (7.0–7.3)

0.1 (−0.3 to 0.9)

0.191

 RR

/min

35.0 (33.8–37.3)

34.0 (31.0–36.3)

36..0 (34.5–37.5)

−2.0 (−8.0 to 2.0)

0.332

 MV

l/min

9.5 (9.0–11.6)

9.1 (8.9–9.4)

11.6 (10.1–11.8)

−2.4 (−4.3 to −0.1)

0.041*

Ppeak

cm H2O

19.5 (18.0–22.5)

18.5 (18.0–19.8)

23.0 (19.0–27.0)

−4.0 (−10.0 to 1.0)

0.195

 ΔP

cm H2O

14.5 (13.0–17.5)

13.5 (13.0–14.8)

18.0 (14.0–22.0)

−4.0 (−10.0 to 1.0)

0.195

Pes

cm H2O

12.0 (12.0–15.0)

12.0 (12.0–15.0)

12.5 (12.0–14.5)

0.0 (− 4.0 to 3.0)

0.924

 paCO2

Torr

41.1 (39.3–43.3)

40.4 (39.0–42.8)

41.8 (40.0–42.9)

−0.9 (−4.6 to 2.5)

0.699

kPa

5.47 (5.24–5.77)

5.38 (5.20–5.70)

5.57 (5.33–57.20)

−0.12 (− 0.61 to 0.33)

 

 paO2

Torr

120.5 (97.8–127.3)

113.5 (99.8–123.5)

123.0 (95.8–130.8)

−4.5 (−30.0 to 34.0)

0.818

kPa

16.07 (13.03–16.97)

15.13 (13.30–16.47)

16.40 (12.77–17.43)

−0.60 (−4.00 to 4.53)

 
  1. CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, HR heart rate, MAP mean arterial pressure, MD mean difference, MPAP mean pulmonary arterial pressure, MV respiratory minute volume, paCO2 arterial partial pressure of carbon dioxide, paO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, Pes esophageal pressure, Ppeak peak pressure, RR respiratory rate, VT tidal volume, ΔP driving pressure (difference between positive end-expiratory pressure and peak pressure);
  2. Binary data are presented as no./total no. (%), continuous data as medians (25th to 75th percentile)
  3. aOdds ratios for binary variables and estimated median difference for continuous variables
  4. bAssessed by Fisher’s exact test for categorical variables and Wilcoxon rank sum test for continuous variables