Table 3 Main clinical parameters at monitoring time points 12, 24, 48, and 72 h

GCS

3 (31 100%)

3 (30 100%)

3 (25 92.6%)

3 (20 90.9%)

7 (1 3.7%)

6 (1 4.5%)

8 (1 3.7%)

9 (1 4.5%)

Heart rate (bpm)

87.82 ± 18.42

93.62 ± 21.76

90.70 ± 17.45

90.73 ± 17.63

 Rhythmic

26 (83.9%)

25 (83.3%)

25 (92.6%)

20 (90.9%)

 Arrhythmic

4 (12.9%)

5 (16.7%)

2 (7.4%)

2 (9.1%)

Systolic pressure (mmHg)

118 (19)

120 (30)

120 (33)

132 (40)

Diastolic pressure (mmHg)

64 ± 10

67 ± 10

66 ± 12

67 ± 14

Mean pressure (mmHg)

80 (13)

84 (17)

87 (24)

88 (26)

Vasoactive drugs

19 (51.4%)

11 (36.7%)

5 (18.5%)

5 (22.7%)

 Adrenaline

0 (0%)

0 (0%)

0 (0%)

0 (0%)

 Noradrenaline

19 (51.4%)

11 (36.7%)

5 (18.5%)

5 (22.7%)

 Vasopressin

0 (0%)

0 (0%)

0 (0%)

0 (0%)

 Dobutamine

1 (3.2%)

1 (3.3%)

0 (0%)

0 (0%)

 Dopamine

0 (0%)

0 (0%)

0 (0%)

0 (0%)

Vasoactive Inotropic Score (VIS)

4 (10)

0 (12.5)

0 (0)

0 (0)

V_T settings (ml)

427 ± 73

433 ± 72

484 ± 71

467 ± 69

RR (breaths/min)

23 ± 4

22 ± 5

23 ± 5

24 ± 4

PEEP (cmH₂O)

13 ± 3

12 ± 3

12 ± 3

12 ± 3

PIP (cmH₂O)

312 ± 8

30 ± 8

29 ± 13

40 ± 9

Mean airway pressure (cmH₂O)

25 (6)

24 (3)

23 (3)

23 (3)

P_Plat (cmH₂O)

26 ± 4

25 ± 4

26 ± 5

27 ± 5

Compliance

39 ± 10

44 ± 16

39 ± 13

38 ± 14

FiO₂ (%)

70 (20)

67.5 (25)

60 (20)

60 (20)

PaO₂ (mmHg)

96 ± 30

91 ± 27

101 ± 30

98 ± 28

PaO₂/FiO₂

145 ± 56

146 ± 55

170 ± 57

168 ± 47

SaO₂ (%)

96 (4)

96 (4)

97 (3)

96 (4)

PaCO₂ (mmHg)

50 ± 9

50 ± 11

51 ± 13

54 ± 16

A-a O₂ gradient

339.1 ± 112.8

318.2 ± 113.3

280.8 ± 108.7

263.8 ± 79.9

pH

7.32 ± 0.08

7.36 ± 0.08

7.39 ± 0.07

7.39 ± 0.04

Lactates (mmol/L)

14 (10.2)

1.4 (0.9)

1.2 (0.4)

1.1 (0.4)

Sodium (mmol/L)

139 (6)

138 (5)

136 (4)

135 (7)

Potassium (mmol/L)

4.1 ± 0.7

4.1 ± 0.7

4.1 ± 0.6

4 ± 0.6

Magnesium (mg/dL)

2 ± 0.6

2 ± 0.6

1.7 ± 0.5

1.8 ± 0.4

Phosphate (mg/dL)

3.3 ± 1.2

3.6 ± 1.1

3.4 ± 1.2

3.5 ± 1

Bicarbonate (mEq/L)

24 ± 4

23 ± 3

24 ± 3

24 ± 3

Hematocrit (%)

34 ± 5.2

33.3 ± 6.6

33.3 ± 6.4

32.8 ± 5.3

Current creatinine (mg/dL)

1.92 (1.31)

1.34 (1.19)

1.31 (0.85)

1.36 (1.31)

Urinary output (ml/h)

25 (45)

15 (65)

10 (50)

2.5 (80)

24 h urinary output

400 (855)

510 (1245)

120 (1470)

90 (1485)

Urea (mg/dL)

54 (92)

51 (60)

47.5 (33)

48 (39)

Bilirubin (mg/dl)

0.8 (1.7)

0.8 (1.9)

0.7 (1.6)

0.7 (1.6)

Albumin (g/dl)

2.7 (0.3)

2.8 (0.3)

2.8 (0.4)

2.9 (0.4)

Platelets (10^3/μl)

210 (145)

219 (150)

215 (148)

218 (115)

INR

1.1 (0.3)

1.1 (0.3)

1.1 (0.1)

1.1 (0.1)

Antithrombin (%)

76 ± 26

83 ± 24

84 ± 19

84 ± 13

Fibrinogen (mg/dl)

650 (163)

611 (183)

630 (323)

624 (250)

D-dimers (ng/ml)

2900 (5845)

2500 (5608)

1629 (3513)

1500 (1900)

PCT (ng/ml)

0.62 (2.07)

0.62 (2.07)

0.56 (2.15)

1.1 (1.36)

Temperature (°C)

36.2 ± 0.7

36.2 ± 0.9

36.4 ± 0.8

36 ± 0.7

CRP (mg/L)

150 (123.2)

135 (131)

133 (130)

128 (122)

WBC (10^3/μl)

11 (5.87)

10.90 (6.62)

12.55 (8.43)

14.32 (6.75)

Ferritin (ng/ml)

408 ± 333

900 ± 887

761 ± 1045

2033 ± 2855

IL-6 (ng/l)

631.5 (165)

645 (881)

320 (259)

159.5 (141)

Total SOFA Score

12 (7)

11 (6.5)

8 (5)

8.5 (4)

Qb (ml/min)

150 (20)

150 (20)

150 (20)

150 (0)

Qd (ml/h)

1000 (700)

1000 (600)

1000 (700)

1000 (600)

Qr pre dilution (ml/h)

0 (0)

0 (0)

0 (0)

0 (0)

Qr post dilution (ml/h)

630 ± 414

665 ± 446

527 ± 347

606 ± 320

Q PBP - citrate infusion (ml/h)

1400 (500)

1350 (500)

1500 (300)

1500 (200)

UF net (ml/h)

80 (100)

70 (100)

50 (100)

100 (130)

Current dose (ml/kg/h)

29 (8)

29 (10)

29 (7)

30 (8)

Filtration fraction (%)

28.5 ± 5.3

27.9 ± 7

28.2 ± 6

28.2 ± 6.8