Fig. 6
From: Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Effects of Flt3-Ligand on lung immune cell populations and on outcomes of lung infection. a Flow cytometry of monocyte/DC progenitors in the bone marrow of mice treated or not (controls) with 7-day oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not. b Flow cytometry of immune cells from lungs of mice with 7-day oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not. c, d Lung and spleen bacterial counts and e alveolar-capillary barrier permeability, measured in mice treated or not (controls) with 7-day oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not. For all experiments, group size is 5 mice per group; results are shown as mean ± SD; *p < 0.05. e Survival of mice after lethal P. aeruginosa pneumonia treated or not by FMT or Flt3-L; group size is 10 mice per group; *p < 0.05