Dose 2 (n = 20) | Dose 3 (n = 9) | Dose 4 (n = 7) | Dose 5 (n = 4) | |||||
---|---|---|---|---|---|---|---|---|
Δ Effect size | p | Δ Effect size | p | Δ Effect size | p | Δ Effect size | p | |
(Δ, % Baseline) | ||||||||
Invasive rCBF | − 3.8 [− 12.0, 0.6] | 0.058 | − 4.2 [− 4.8, 0.7] | 0.469 | − 2.7 [− 8.2, − 0.7] | 0.219 | − 2.2 [− 6.1, 2.6] | 0.625 |
Non-invasive rCBF | − 3.0 [− 13.7, 1.0] | 0.098 | − 5.0 [− 11.0, 4.9] | 0.375 | − 1.3 [− 4.1, 0.3] | 0.438 | − 10.6 [− 14.1, 6.1] | 0.750 |
rPbtO2 | − 5.4 [− 22.0, 0.6] | 0.044 | − 1.6 [− 26.0, 1.9] | 0.426 | −1.6 [− 6.1, 1.5] | 0.578 | −2.7 [− 4.7, − 0.5] | 0.250 |
rStO2 | − 3.6 [− 10.4, 0.7] | 0.005* | − 6.0 [− 8.9, − 2.9] | 0.008* | − 5.3 [− 6.6, − 4.2] | 0.016* | − 5.0 [− 7.5, − 3.9] | 0.125 |
rTHC | − 1.9 [− 5.7, 1.3] | 0.030 | − 2.9 [− 5.6, 1.6] | 0.250 | − 1.5 [− 4.6, 1.5] | 0.578 | − 1.7 [− 4.8, 0.2] | 0.375 |
r [HbO2] | − 3.9 [− 12.1, 0.1] | 0.005* | − 7.6 [− 13.3, − 2.2] | 0.004* | − 7.3 [− 8.0, − 4.5] | 0.016* | − 4.8 [− 9.1, − 4.3] | 0.125 |
r [Hb] | − 0.4 [− 3.1, 7.4] | 0.351 | + 1.1 [− 0.7, 10.8] | 0.301 | + 2.5 [0.0, 7.7] | 0.109 | + 1.2 [− 1.3, 5.3] | 0.625 |
(Δ, mmHg) | ||||||||
SBP | − 5.9 [− 24.2, 3.0] | 0.062 | + 1.8 [− 16.4, 12.1] | > 0.999 | − 2.1 [− 10.6, 7.4] | 0.578 | − 10.7 [− 36.9, 1.5] | 0.375 |
DBP | − 0.6 [− 5.8, 1.0] | 0.117 | − 7.3 [− 8.1, 1.0] | 0.203 | − 2.5 [− 5.5, 1.2] | 0.297 | − 3.2 [− 10.5, 1.3] | 0.625 |
CPP | − 1.0 [− 5.7, 1.2] | 0.086 | − 4.4 [− 7.4, 1.8] | 0.359 | − 1.5 [− 4.7, 1.6] | 0.469 | − 2.7 [− 8.9, 1.3] | 0.375 |