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Table 2 Change in dose efficacy with repeated doses of intra-arrest epinephrine, comparison to dose 1

From: Epinephrine’s effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation

 

Dose 2 (n = 20)

 

Dose 3 (n = 9)

 

Dose 4 (n = 7)

 

Dose 5 (n = 4)

 
 

Δ Effect size

p

Δ Effect size

p

Δ Effect size

p

Δ Effect size

p

(Δ, % Baseline)

Invasive rCBF

− 3.8 [− 12.0, 0.6]

0.058

− 4.2 [− 4.8, 0.7]

0.469

− 2.7 [− 8.2, − 0.7]

0.219

− 2.2 [− 6.1, 2.6]

0.625

Non-invasive rCBF

− 3.0 [− 13.7, 1.0]

0.098

− 5.0 [− 11.0, 4.9]

0.375

− 1.3 [− 4.1, 0.3]

0.438

− 10.6 [− 14.1, 6.1]

0.750

rPbtO2

− 5.4 [− 22.0, 0.6]

0.044

− 1.6 [− 26.0, 1.9]

0.426

−1.6 [− 6.1, 1.5]

0.578

−2.7 [− 4.7, − 0.5]

0.250

rStO2

− 3.6 [− 10.4, 0.7]

0.005*

− 6.0 [− 8.9, − 2.9]

0.008*

− 5.3 [− 6.6, − 4.2]

0.016*

− 5.0 [− 7.5, − 3.9]

0.125

rTHC

− 1.9 [− 5.7, 1.3]

0.030

− 2.9 [− 5.6, 1.6]

0.250

− 1.5 [− 4.6, 1.5]

0.578

− 1.7 [− 4.8, 0.2]

0.375

r [HbO2]

− 3.9 [− 12.1, 0.1]

0.005*

− 7.6 [− 13.3, − 2.2]

0.004*

− 7.3 [− 8.0, − 4.5]

0.016*

− 4.8 [− 9.1, − 4.3]

0.125

r [Hb]

− 0.4 [− 3.1, 7.4]

0.351

+ 1.1 [− 0.7, 10.8]

0.301

+ 2.5 [0.0, 7.7]

0.109

+ 1.2 [− 1.3, 5.3]

0.625

(Δ, mmHg)

SBP

− 5.9 [− 24.2, 3.0]

0.062

+ 1.8 [− 16.4, 12.1]

> 0.999

− 2.1 [− 10.6, 7.4]

0.578

− 10.7 [− 36.9, 1.5]

0.375

DBP

− 0.6 [− 5.8, 1.0]

0.117

− 7.3 [− 8.1, 1.0]

0.203

− 2.5 [− 5.5, 1.2]

0.297

− 3.2 [− 10.5, 1.3]

0.625

CPP

− 1.0 [− 5.7, 1.2]

0.086

− 4.4 [− 7.4, 1.8]

0.359

− 1.5 [− 4.7, 1.6]

0.469

− 2.7 [− 8.9, 1.3]

0.375

  1. Effect Size reported as median [interquartile range]
  2. Abbreviations: Δ change in value, n sample size, rCBF relative cerebral blood flow, rPbtO2 relative partial pressure of oxygen in brain tissue, rStO2 relative cerebral tissue oxygen saturation, rTHC relative total hemoglobin concentration, r [HbO2] relative concentration of oxy-hemoglobin, r [Hb] relative concentration of deoxy-hemoglobin, SBP systolic aortic blood pressure, DBP diastolic aortic blood pressure, CPP coronary perfusion pressure
  3. *Adjusted p < 0.05 after false discovery rate correction for repeated comparisons