Skip to main content

Table 2 Change in dose efficacy with repeated doses of intra-arrest epinephrine, comparison to dose 1

From: Epinephrine’s effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation

  Dose 2 (n = 20)   Dose 3 (n = 9)   Dose 4 (n = 7)   Dose 5 (n = 4)  
  Δ Effect size p Δ Effect size p Δ Effect size p Δ Effect size p
(Δ, % Baseline)
Invasive rCBF − 3.8 [− 12.0, 0.6] 0.058 − 4.2 [− 4.8, 0.7] 0.469 − 2.7 [− 8.2, − 0.7] 0.219 − 2.2 [− 6.1, 2.6] 0.625
Non-invasive rCBF − 3.0 [− 13.7, 1.0] 0.098 − 5.0 [− 11.0, 4.9] 0.375 − 1.3 [− 4.1, 0.3] 0.438 − 10.6 [− 14.1, 6.1] 0.750
rPbtO2 − 5.4 [− 22.0, 0.6] 0.044 − 1.6 [− 26.0, 1.9] 0.426 −1.6 [− 6.1, 1.5] 0.578 −2.7 [− 4.7, − 0.5] 0.250
rStO2 − 3.6 [− 10.4, 0.7] 0.005* − 6.0 [− 8.9, − 2.9] 0.008* − 5.3 [− 6.6, − 4.2] 0.016* − 5.0 [− 7.5, − 3.9] 0.125
rTHC − 1.9 [− 5.7, 1.3] 0.030 − 2.9 [− 5.6, 1.6] 0.250 − 1.5 [− 4.6, 1.5] 0.578 − 1.7 [− 4.8, 0.2] 0.375
r [HbO2] − 3.9 [− 12.1, 0.1] 0.005* − 7.6 [− 13.3, − 2.2] 0.004* − 7.3 [− 8.0, − 4.5] 0.016* − 4.8 [− 9.1, − 4.3] 0.125
r [Hb] − 0.4 [− 3.1, 7.4] 0.351 + 1.1 [− 0.7, 10.8] 0.301 + 2.5 [0.0, 7.7] 0.109 + 1.2 [− 1.3, 5.3] 0.625
(Δ, mmHg)
SBP − 5.9 [− 24.2, 3.0] 0.062 + 1.8 [− 16.4, 12.1] > 0.999 − 2.1 [− 10.6, 7.4] 0.578 − 10.7 [− 36.9, 1.5] 0.375
DBP − 0.6 [− 5.8, 1.0] 0.117 − 7.3 [− 8.1, 1.0] 0.203 − 2.5 [− 5.5, 1.2] 0.297 − 3.2 [− 10.5, 1.3] 0.625
CPP − 1.0 [− 5.7, 1.2] 0.086 − 4.4 [− 7.4, 1.8] 0.359 − 1.5 [− 4.7, 1.6] 0.469 − 2.7 [− 8.9, 1.3] 0.375
  1. Effect Size reported as median [interquartile range]
  2. Abbreviations: Δ change in value, n sample size, rCBF relative cerebral blood flow, rPbtO2 relative partial pressure of oxygen in brain tissue, rStO2 relative cerebral tissue oxygen saturation, rTHC relative total hemoglobin concentration, r [HbO2] relative concentration of oxy-hemoglobin, r [Hb] relative concentration of deoxy-hemoglobin, SBP systolic aortic blood pressure, DBP diastolic aortic blood pressure, CPP coronary perfusion pressure
  3. *Adjusted p < 0.05 after false discovery rate correction for repeated comparisons