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Table 1 Demographics and laboratory data at admission of patients infected with COVID-19 according to the time to SARS-CoV-2 RNA clearance

From: Glucocorticoid therapy does not delay viral clearance in COVID-19 patients

 

Overall (N = 684)

≤ 14 days (N = 202)

14–28 days (N = 210)

> 28 days (N = 272)

p value

Demographics, clinical characteristics

 Age (years)

61.0 [49.0, 70.0]

62.0 [48.0, 71.0]

60.5 [49.3, 70.0]

61.5 [51.0, 70.3]

0.733

 Gender (%)

0.841

  Male

328 (48.0)

98 (48.5)

103 (49.3)

127 (46.7)

 

  Female

355 (52.0)

104 (51.5)

106 (50.7)

145 (53.3)

 

 Clinical type (%)

0.009

  Mild

26 (3.9)

16 (8.0)

7 (3.4)

3 (1.1)

 

  General

464 (69.3)

140 (70.0)

141 (69.1)

183 (68.8)

 

  Severe

145 (21.6)

36 (18.0)

44 (21.6)

65 (24.4)

 

  Critical

35 (5.2)

8 (4.0)

12 (5.9)

15 (5.6)

 

 Hypertension (%)

235 (35.0)

67 (34.0)

70 (33.8)

98 (36.6)

0.778

 CHD (%)

75 (11.2)

22 (11.2)

25 (12.1)

28 (10.4)

0.855

 CRF (%)

16 (2.4)

3 (1.5)

7 (3.4)

6 (2.2)

0.467

 DM (%)

111 (16.5)

30 (15.2)

36 (17.5)

45 (16.8)

0.824

 COPD (%)

13 (1.9)

3 (1.5)

3 (1.4)

7 (2.6)

0.588

 Cirrhosis (%)

3 (0.4)

0 (0.0)

1 (0.5)

2 (0.7)

0.492

 Stroke (%)

45 (6.7)

14 (7.1)

14 (6.8)

17 (6.3)

0.943

 Tumor (%)

23 (3.4)

5 (2.6)

5 (2.4)

13 (4.9)

0.257

Inflammatory response, median (IQR)

 CRP (mg/L)

7.39 [0.50, 28.25]

8.63 [1.04, 16.33]

5.79 [0.50, 28.80]

5.13 [0.50, 62.39]

0.968

 IL-6 (pg/mL)

6.00 [2.25, 21.00]

6.00 [3.00, 19.50]

7.50 [2.00, 26.25]

6.00 [3.00, 20.50]

0.943

 Fib (g/L)

4.82 [3.68, 11.90]

4.46 [3.58, 11.72]

5.50 [3.65, 11.98]

6.71 [4.08, 13.60]

0.19

 WBC (109/L)

5.59 [4.46, 7.06]

5.60 [4.47, 6.79]

5.51 [4.52, 7.12]

5.33 [4.38, 7.83]

0.962

 Neutrophil (109/L)

3.33 [2.44, 4.76]

3.33 [2.49, 4.51]

3.31 [2.42, 4.85]

3.67 [2.41, 5.83]

0.618

 Monocyte (109/L)

0.46 [0.34, 0.60]

0.45 [0.35, 0.59]

0.46 [0.34, 0.61]

0.47 [0.35, 0.58]

0.970

 Lymphocyte (109/L)

1.27 [0.88, 1.81]

1.29 [0.94, 1.86]

1.29 [0.95, 1.73]

1.00 [0.72, 1.67]

0.204

 PLT (109/L)

203 [158, 249]

209 [156, 267]

196 [158, 241]

189 [148, 244]

0.209

 Hb (g/L)

121 [108, 133]

123 [109, 133]

121 [110, 131]

121 [103, 131]

0.609

 CD3 (count/μL)

8905 [474, 1212]

916 [586, 1220]

705 [423, 1224]

497 [364, 684]

0.115

 CD4 (count/μL)

478 [269, 672]

554 [319, 733]

324 [190, 588]

275 [154, 404]

0.048

 CD8 (count/μL)

248 [150, 374]

291 [174, 400]

229 [142, 367]

167 [123, 211]

0.112

 NK (count/μL)

167 [103, 259]

142 [91.0, 231]

206 [141, 332]

154 [91.8, 215]

0.115

 B cell (count/μL)

175 [104, 281]

195 [131, 296]

187 [91.0, 279]

94.0 [72.8, 126]

0.030

Organ function measurement, median (IQR)

 ALT (U/L)

27.0 [18.0, 41.0]

26.0 [18.0, 40.5]

29.0 [19.0, 43.0]

27.0 [18.3, 38.3]

0.679

 AST (U/L)

22.0 [16.0, 36.5]

20.0 [15.0, 36.0]

23.0 [17.0, 37.0]

23.0 [19.0, 39.0]

0.314

 TBIL (μmol/L)

11.2 [8.40, 14.0]

11.3 [8.7, 14.0]

11.0 [8.30, 13.0]

11.1 [8.53, 15.8]

0.731

 DBIL (μmol/L)

2.80 [2.10, 3.70]

2.70 [2.20, 3.60]

3.00 [1.92, 3.68]

2.90 [1.90, 4.40]

0.935

 Creatinine (μmol/L)

61.0 [50.0, 75.0]

61.0 [50.0, 78.5]

60.0 [50.2, 74.7]

60.0 [50.2, 72.5]

0.694

 BUN (mmol/L)

4.60 [3.60, 5.80]

4.40 [3.50, 5.80]

4.60 [3.70, 5.50]

4.50 [3.70, 5.80]

0.794

 Lactate (mmol/L)

1.10 [1.00, 1.35]

1.00 [0.90, 1.30]

1.10 [1.00, 1.30]

1.10 [1.00, 1.60]

0.395

 Glucose (mmol/L)

5.60 [5.00, 6.62]

5.55 [5.00, 6.32]

5.60 [5.03, 7.62]

5.30 [4.90, 6.95]

0.431

 INR

1.10 [1.00, 1.20]

1.10 [1.00, 1.20]

1.10 [1.00, 1.20]

1.10 [1.10, 1.20]

0.075

 CK (U/L)

66.5 [25.3, 110.5]

67.0 [24.0, 107.5]

62.0 [39.0, 135.0]

63.0 [22.5, 105.5]

0.530

 BNP (pg/mL)

67.9 [28.0, 152.3]

67.9 [28.0, 243.0]

62.0 [27.0, 126.0]

97.0 [41.5, 128.8]

0.490

 NT-proBNP (pg/mL)

745 [88.0, 1899]

109 [67.0, 2679]

1118 [769.5, 2237]

745 [382, 859]

0.532

GC treatment (%)

103 (15.1)

24 (11.9)

32 (15.2)

47 (17.3)

0.266

 Methylprednisolone (%)

96 (14.0)

24 (11.9)

30 (14.3)

42 (15.4)

0.540

 Dexamethasone (%)

12 (1.8)

2 (1.0)

3 (1.4)

7 (2.6)

0.392

 Hydrocortisone (%)

1 (0.1)

0 (0.0)

0 (0.0)

1 (0.4)

0.468

Outcome

 Hospital stay (days)

25.0 [16.0, 38.0]

21.0 [14.0, 28.0]

24.0 [18.0, 32.0]

37.0 [21.0, 47.0]

< 0.001

 Total course (days)

45.0 [33.0, 59.3]

30.0 [19.5, 39.5]

41.0 [32.0, 54.0]

57.0 [47.0, 67.0]

< 0.001

 Outcome (%)

0.414

  Survival

643 (96.8)

191 (97.0)

194 (95.6)

258 (97.7)

 

  Death

21 (3.2)

6 (3.0)

9 (4.4)

6 (2.3)

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