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Table 1 Demographics and laboratory data at admission of patients infected with COVID-19 according to the time to SARS-CoV-2 RNA clearance

From: Glucocorticoid therapy does not delay viral clearance in COVID-19 patients

  Overall (N = 684) ≤ 14 days (N = 202) 14–28 days (N = 210) > 28 days (N = 272) p value
Demographics, clinical characteristics
 Age (years) 61.0 [49.0, 70.0] 62.0 [48.0, 71.0] 60.5 [49.3, 70.0] 61.5 [51.0, 70.3] 0.733
 Gender (%) 0.841
  Male 328 (48.0) 98 (48.5) 103 (49.3) 127 (46.7)  
  Female 355 (52.0) 104 (51.5) 106 (50.7) 145 (53.3)  
 Clinical type (%) 0.009
  Mild 26 (3.9) 16 (8.0) 7 (3.4) 3 (1.1)  
  General 464 (69.3) 140 (70.0) 141 (69.1) 183 (68.8)  
  Severe 145 (21.6) 36 (18.0) 44 (21.6) 65 (24.4)  
  Critical 35 (5.2) 8 (4.0) 12 (5.9) 15 (5.6)  
 Hypertension (%) 235 (35.0) 67 (34.0) 70 (33.8) 98 (36.6) 0.778
 CHD (%) 75 (11.2) 22 (11.2) 25 (12.1) 28 (10.4) 0.855
 CRF (%) 16 (2.4) 3 (1.5) 7 (3.4) 6 (2.2) 0.467
 DM (%) 111 (16.5) 30 (15.2) 36 (17.5) 45 (16.8) 0.824
 COPD (%) 13 (1.9) 3 (1.5) 3 (1.4) 7 (2.6) 0.588
 Cirrhosis (%) 3 (0.4) 0 (0.0) 1 (0.5) 2 (0.7) 0.492
 Stroke (%) 45 (6.7) 14 (7.1) 14 (6.8) 17 (6.3) 0.943
 Tumor (%) 23 (3.4) 5 (2.6) 5 (2.4) 13 (4.9) 0.257
Inflammatory response, median (IQR)
 CRP (mg/L) 7.39 [0.50, 28.25] 8.63 [1.04, 16.33] 5.79 [0.50, 28.80] 5.13 [0.50, 62.39] 0.968
 IL-6 (pg/mL) 6.00 [2.25, 21.00] 6.00 [3.00, 19.50] 7.50 [2.00, 26.25] 6.00 [3.00, 20.50] 0.943
 Fib (g/L) 4.82 [3.68, 11.90] 4.46 [3.58, 11.72] 5.50 [3.65, 11.98] 6.71 [4.08, 13.60] 0.19
 WBC (109/L) 5.59 [4.46, 7.06] 5.60 [4.47, 6.79] 5.51 [4.52, 7.12] 5.33 [4.38, 7.83] 0.962
 Neutrophil (109/L) 3.33 [2.44, 4.76] 3.33 [2.49, 4.51] 3.31 [2.42, 4.85] 3.67 [2.41, 5.83] 0.618
 Monocyte (109/L) 0.46 [0.34, 0.60] 0.45 [0.35, 0.59] 0.46 [0.34, 0.61] 0.47 [0.35, 0.58] 0.970
 Lymphocyte (109/L) 1.27 [0.88, 1.81] 1.29 [0.94, 1.86] 1.29 [0.95, 1.73] 1.00 [0.72, 1.67] 0.204
 PLT (109/L) 203 [158, 249] 209 [156, 267] 196 [158, 241] 189 [148, 244] 0.209
 Hb (g/L) 121 [108, 133] 123 [109, 133] 121 [110, 131] 121 [103, 131] 0.609
 CD3 (count/μL) 8905 [474, 1212] 916 [586, 1220] 705 [423, 1224] 497 [364, 684] 0.115
 CD4 (count/μL) 478 [269, 672] 554 [319, 733] 324 [190, 588] 275 [154, 404] 0.048
 CD8 (count/μL) 248 [150, 374] 291 [174, 400] 229 [142, 367] 167 [123, 211] 0.112
 NK (count/μL) 167 [103, 259] 142 [91.0, 231] 206 [141, 332] 154 [91.8, 215] 0.115
 B cell (count/μL) 175 [104, 281] 195 [131, 296] 187 [91.0, 279] 94.0 [72.8, 126] 0.030
Organ function measurement, median (IQR)
 ALT (U/L) 27.0 [18.0, 41.0] 26.0 [18.0, 40.5] 29.0 [19.0, 43.0] 27.0 [18.3, 38.3] 0.679
 AST (U/L) 22.0 [16.0, 36.5] 20.0 [15.0, 36.0] 23.0 [17.0, 37.0] 23.0 [19.0, 39.0] 0.314
 TBIL (μmol/L) 11.2 [8.40, 14.0] 11.3 [8.7, 14.0] 11.0 [8.30, 13.0] 11.1 [8.53, 15.8] 0.731
 DBIL (μmol/L) 2.80 [2.10, 3.70] 2.70 [2.20, 3.60] 3.00 [1.92, 3.68] 2.90 [1.90, 4.40] 0.935
 Creatinine (μmol/L) 61.0 [50.0, 75.0] 61.0 [50.0, 78.5] 60.0 [50.2, 74.7] 60.0 [50.2, 72.5] 0.694
 BUN (mmol/L) 4.60 [3.60, 5.80] 4.40 [3.50, 5.80] 4.60 [3.70, 5.50] 4.50 [3.70, 5.80] 0.794
 Lactate (mmol/L) 1.10 [1.00, 1.35] 1.00 [0.90, 1.30] 1.10 [1.00, 1.30] 1.10 [1.00, 1.60] 0.395
 Glucose (mmol/L) 5.60 [5.00, 6.62] 5.55 [5.00, 6.32] 5.60 [5.03, 7.62] 5.30 [4.90, 6.95] 0.431
 INR 1.10 [1.00, 1.20] 1.10 [1.00, 1.20] 1.10 [1.00, 1.20] 1.10 [1.10, 1.20] 0.075
 CK (U/L) 66.5 [25.3, 110.5] 67.0 [24.0, 107.5] 62.0 [39.0, 135.0] 63.0 [22.5, 105.5] 0.530
 BNP (pg/mL) 67.9 [28.0, 152.3] 67.9 [28.0, 243.0] 62.0 [27.0, 126.0] 97.0 [41.5, 128.8] 0.490
 NT-proBNP (pg/mL) 745 [88.0, 1899] 109 [67.0, 2679] 1118 [769.5, 2237] 745 [382, 859] 0.532
GC treatment (%) 103 (15.1) 24 (11.9) 32 (15.2) 47 (17.3) 0.266
 Methylprednisolone (%) 96 (14.0) 24 (11.9) 30 (14.3) 42 (15.4) 0.540
 Dexamethasone (%) 12 (1.8) 2 (1.0) 3 (1.4) 7 (2.6) 0.392
 Hydrocortisone (%) 1 (0.1) 0 (0.0) 0 (0.0) 1 (0.4) 0.468
Outcome
 Hospital stay (days) 25.0 [16.0, 38.0] 21.0 [14.0, 28.0] 24.0 [18.0, 32.0] 37.0 [21.0, 47.0] < 0.001
 Total course (days) 45.0 [33.0, 59.3] 30.0 [19.5, 39.5] 41.0 [32.0, 54.0] 57.0 [47.0, 67.0] < 0.001
 Outcome (%) 0.414
  Survival 643 (96.8) 191 (97.0) 194 (95.6) 258 (97.7)  
  Death 21 (3.2) 6 (3.0) 9 (4.4) 6 (2.3)