Table 2 Respiratory and hemodynamic data according to native cardiac output (NCO) < 1 L/min versus ≥ 1 L/min
NCO < 1 L/min (n = 51) | NCO ≥ 1 L/min (n = 145) | p value | |
|---|---|---|---|
VA-ECLS and ventilator data | |||
VA-ECLS flow (Q ECLS), L/min | 3.2 [2.9–4] | 2.9 [2.2–3.8] | < 0.01 |
VA-ECLS sweep gas flow (V ECLS), L/min | 5 [4–6] | 4 [3–5] | < 0.01 |
V/Q ECLS | 1.3 [1.2–1.7] | 1.4 [1.1–1.8] | 0.96 |
Tidal volume, mL | 300 [260–350] | 320 [300–360] | < 0.001 |
Respiratory rate, breaths/min | 12 [11–14] | 12 [11–14] | 0.65 |
Ventilator minute volume (V lung), L/min | 3.6 [3–4] | 3.9 [3.5–4.7] | < 0.01 |
Positive end-expiratory pressure, cmH2O | 10 [8–10] | 10 [8–10] | 0.91 |
Plateau pressure, cmH2O | 18 [17–21] | 18 [16–20] | 0.26 |
V lung/V ECLS | 0.8 [0.6–1] | 1.1 [0.8–1.2] | < 0.001 |
Hemodynamic data | |||
Heart rate, beats/min | 88 [73–107] | 87 [72–106] | 0.66 |
Right atrium pressure, mmHg | 7 [5–8] | 11 [8–13] | 0.01 |
PA systolic pressure, mmHg | 15 [12–18] | 26 [23–34] | < 0.001 |
PA diastolic pressure, mmHg | 12 [9–15] | 19 [16–21] | < 0.001 |
Mean PA pressure, mmHg | 13 [10–17] | 21 [18–26] | < 0.001 |
PA wedge pressure, mmHg | 10 [8–12] | 14 [11–16] | 0.01 |
NCO, L/min | 0.5 [0.15–0.5] | 1.8 [1.4–2.7] | < 0.001 |
Systolic BP, mmHg | 79 [73–88] | 95 [84–109] | < 0.001 |
Diastolic BP, mmHg | 73 [67–79] | 70 [63–77] | 0.13 |
Pulse pressure, mmHg | 9 [0–14] | 31 [20–42] | < 0.001 |
Mean BP, mmHg | 74 [69–80] | 78 [72–87] | < 0.01 |
SvO2 (%) | 74 [72–78] | 72 [66–77] | 0.10 |
Respiratory data | |||
PaCO2, mmHg | 35 [33–40] | 37 [34–41] | 0.26 |
EtCO2, mmHg | 9 [2–12] | 23 [17–28] | < 0.001 |
PaCO2-EtCO2, mmHg | 30 [22–33] | 13 [8–19] | < 0.001 |
Adjuvant treatments | |||
Norepinephrine (mg/h) | 3.2 [2.9–4] | 1.2 [0.2–0.4] | < 0.01 |
Inotropic support | 34 (67) | 41 (28) | < 0.001 |
Inhaled NO | 12 (23) | 21 (14) | 0.07 |
Transient or durable left VAD | 11 (21) | 38 (26) | 0.57 |