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Table 8 Ongoing clinical trials optimizing prophylactic anticoagulation regimens in COVID-19

From: Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations

NCT number

Study name

Interventions

Sponsor

NCT04409834

Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial

Evaluation of varying anticoagulation strategies including UFH IV, UFH SC, enoxaparin 1 mg/kg, enoxaparin 40 mg SC, and clopidogrel

The TIMI Study Group

NCT04367831

Intermediate or Prophylactic- Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19

Evaluation of prophylactic enoxaparin vs intermediate dosing

Columbia University (USA)

NCT04367831

Patient Characteristics, Outcome and Thromboembolic Events Among Adult Critically Ill COVID-19 Patients with Different Anticoagulant Regimes

Completed dose finding study of tinzaparin

Karolinska Institute (Sweden)

NCT04367831

Preventing COVID-19 Complications with Low- and High-dose Anticoagulation

Evaluating low vs high dose enoxaparin

University Hospital Geneva (Switzerland)

NCT04344756

Trial Evaluating Efficacy and Safety of Anticoagulation in Patients With COVID-19 Infection, Nested in the Corimmuno-19 Cohort

Evaluation of tinzaparin vs UFH anticoagulation

Assistance Publique – Hȏpitaux de Paris (France)

NCT04360824

Covid-19 Associated Coagulopathy

Evaluation of prophylactic vs intermediate dose thromboprophylaxis

University of Iowa (USA)

NCT04360824

Full Dose Heparin Vs. Prophylactic or Intermediate Dose Heparin in High Risk COVID-19 Patients

Evaluation of prophylactic vs intermediate dose thromboprophylaxis

Northwell Health (USA)

NCT04372589

Full Dose Heparin Vs. Prophylactic or Intermediate Dose Heparin in High Risk COVID-19 Patients

Evaluation of heparin dose strategy

University of Manitoba (Canada)

  1. Abbreviations: COVID-19 coronavirus disease 2019, SC subcutaneous, UFH unfractionated heparin