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Table 2 Multivariate binary logistic regression in ICU patients, analysis predicting attainment achieving PDT of (A) 100% ƒT > MIC and (B) 100% ƒT > 4×MIC as the dependent factor

From: Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

Predictor variables

100% ƒT > MIC

100% ƒT > 4×MIC

OR (95% CI)

OR (95% CI)

Male gender

0.32 (0.12–0.81)

0.60 (0.23–1.51)

Age (years)

1.03 (0.99–1.07)

0.98 (0.94–1.01)

BMI (mg/kg2)

0.98 (0.91–1.05)

0.91 (0.83–0.99)

Serum urea (mmol/L)

1.09 (1.03–1.17)

1.05 (1.00–1.10)

eGFR ≥ 90 (mL/min/1.73 m2)

0.69 (0.25–1.94)

0.14 (0.03–0.49)

SOFA score

1.05 (0.96–1.16)

0.95 (0.85–1.05)

CRRT

6.54 (1.47–48.61)

2.26 (0.73–6.97)

Sepsis

1.18 (0.38–3.88)

1.31 (0.43–3.88)

  1. The estimates are odds ratios (ORs) and 95% confidence intervals. The numbers in bold are statistically significant. Statistical significance was accepted at p ≤ 0.05. McFadden R-squared for models A and B are 0.21 and 0.18, respectively, representing good fit
  2. BMI body mass index, CRRT continuous renal replacement therapy, eGFR estimated glomerular filtration rate calculated with the CKD-EPI Creatinine Equation, ƒT > MIC the unbound concentrations above the minimum inhibitory concentration, PDT pharmacodynamic target, SOFA score Sequential Organ Failure Assessment score