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Fig. 2 | Critical Care

Fig. 2

From: Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

Fig. 2

Target attainment in ICU patients for various beta-lactams and dosing regimens to reach the PDTs 100% ƒT > MIC (A1–F1) and 100% ƒT > 4×MIC (A2–F2) for a range of MICs. The numbers of patients (n) are presented per antibiotic and dose regimen. The dotted horizontal line indicates the intercept with the EUCAST epidemiological cut-off (ECOFF) breakpoints: amoxicillin 8 mg/L (Enterobacterales), cefotaxime 4 mg/L (Staphylococcus aureus), ceftazidime 8 mg/L (Pseudomonas aeruginosa), ceftriaxone 0.5 mg/L (Enterobacterales), cefuroxime 8 mg/L (Escherichia coli), and meropenem 2 mg/L (Pseudomonas aeruginosa)

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