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Fig. 1 | Critical Care

Fig. 1

From: Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

Fig. 1

Box (median, 25th and 75th percentiles) and whisker (10th and 90th percentiles) plots of unbound trough (ƒCmin) plasma concentrations observed in critically ill patients treated with beta-lactam antibiotics. The green areas indicate the target exposure (ƒCmin = 1–10×MICECOFF), the blue areas indicate suboptimal exposure (ƒCmin <1×MICECOFF), and the red areas indicate threshold for dose reduction (ƒCmin > 10×MICECOFF). The numbers of trough samples (n) are presented per antibiotic. Outliers are removed using the ROUT method (Q = 0.5%). Filled circles are remaining outliers. *Amoxicillin and amoxicillin/clavulanic acid

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Critical Care

ISSN: 1364-8535