From: Cost-effectiveness of adrenaline for out-of-hospital cardiac arrest
Analysis | Adrenaline | Placebo | Cost-effectiveness | Probability adrenaline is cost-effective at | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Mean costs | Mean QALYs | Mean costs | Mean QALYs | Incremental costs | Incremental QALYs | ICER | £15,000 per QALY | £20,000 per QALY | £30,000 per QALY | |
Trial-based analysis (n = 21,757)1 | £78,130,649 | 54 | £48,662,440 | 37 | £29,468,209 | 17 | £1,693,003 | 0.00 | 0.00 | 0.00 |
Trial-based + extrapolation (n = 21,757) 1 | £115,497,429 | 2414 | £76,885,801 | 1938 | £38,611,628 | 476 | £81,070 | 0.04 | 0.05 | 0.10 |
Trial-based + extrapolation + lung (n = 81) | £120,803,455 | 2642 | £82,061,552 | 2138 | £38,741,903 | 504 | £76,859 | 0.03 | 0.05 | 0.10 |
Trial-based + extrapolation + liver (n = 309) | £163,048,181 | 5452 | £116,865,746 | 4187 | £46,182,436 | 1264 | £36,533 | 0.06 | 0.13 | 0.35 |
Trial-based + extrapolation + kidney (n = 731) | £262,782,220 | 9676 | £220,723,823 | 7398 | £42,058,397 | 2278 | £18,466 | 0.34 | 0.57 | 0.82 |
Trial-based + extrapolation + lung + liver + kidney | £315,638,999 | 12,942 | £265,879,518 | 9849 | £49,759,481 | 3093 | £16,086 | 0.41 | 0.68 | 0.90 |