| All patients (n = 317) | Moderate patients (n = 93) | Severe patients (n = 167) | Critical patients (n = 57) |
---|---|---|---|---|
Characteristics | ||||
 Age, years | 62.0 (51.0–70.0) | 59.0 (46.0–68.5) | 62.0 (51.0–69.0)* | 68.0 (57.0–77.0)* |
 Males, n (%) | 162 (51.1%) | 41 (44.1%) | 90 (53.9%) | 31 (54.4%) |
 Comorbidity | ||||
  Chronic respiratory diseases, n (%) | 19 (6.0%) | 4 (4.3%) | 9 (5.9%) | 6 (10.5%) |
  Hypertension, n (%) | 124 (39.1%) | 40 (43.0%) | 61 (36.5%) | 23 (40.4%) |
  Coronary artery disease, n (%) | 30 (9.5%) | 10 (10.8%) | 14 (8.4%) | 6 (10.5%) |
  Diabetes mellitus, n (%) | 63 (19.9%) | 17 (18.3%) | 30 (18.0%) | 16 (28.1%) |
  Chronic kidney disease, n (%) | 4 (1.3%) | 3 (3.2%) | 1 (0.6%) | 0 |
  Tumor, n (%) | 6 (1.9%) | 3 (3.2%) | 2 (1.2%) | 1 (1.8%) |
Laboratory findings | ||||
 White blood cell count, × 10^9/L | 5.6 (4.4–7.8) | 5.4 (4.2–6.7) | 5.2 (4.2–7.2) | 8.6 (5.9–13.4)*# |
 Neutrophil count, × 10^9/L | 4.0 (2.9–6.3) | 3.5 (2.6–4.3) | 3.9 (2.8–5.4) | 7.5 (4.7–12.4)*# |
 Lymphocyte count, × 10^9/L | 0.9 (0.6–1.3) | 1.0 (0.8–1.5) | 0.9 (0.7–1.2) | 0.6 (0.5–0.8)* |
 Hemoglobin, g/L | 127.0 (116.0–139.0) | 125.0 (114.5–134.0) | 127.0 (116.0–139.0) | 133.0 (117.5–140.5) |
 Platelet count, × 10^9/L | 208.0 (154.0–285.0) | 223.0 (173.0–307.5) | 201.0 (151.0–276.0) | 181.0 (124.0–257.0)* |
 Albumin, g/L | 33.7 (30.8–36.8) | 36.4 (32.9–40.0) | 33.5 (31.2–36.2)* | 30.7 (28.2–33.4)*# |
 Blood bicarbonate ions, mmol/L | 23.5 (21.7–25.1) | 23.9 (21.9–25.6) | 23.6 (22.0–25.0) | 22.2 (19.3–24.3)*# |
 Blood urea nitrogen, mmol/L | 4.6 (3.5–6.0) | 4.0 (3.3–5.0) | 4.4 (3.5–5.5) | 7.2 (5.1–10.7)*# |
 Blood creatinine, μmol/L | 70.0 (57.5–86.0) | 62.0 (55.0–81.5) | 69.0 (59.0–84.0) | 79.0 (62.0–103.5)*# |
 Lactate dehydrogenase, U/L | 302.0 (237.0–425.0) | 234.0 (209.0–283.5) | 307.0 (249.0–392.0)* | 496.0 (415.0–690.0)*# |
 High-sensitivity C-reactive protein, mg/L | 41.1 (11.8–90.6) | 14.0 (4.8–39.7) | 44.1 (15.4–89.0)* | 93.0 (65.0–165.1)*# |
 Procalcitonin, ng/mL | 0.06 (0.03–0.17) | 0.04 (0.02–0.07) | 0.06 (0.03–0.14)* | 0.21 (0.10–0.70)*# |
 Ferritin, μg/L | 751.5 (435.7–1333.9) | 504.0 (282.0–776.4) | 784.0 (456.1–1325.6)* | 1340.0 (884.6–1989.4)*# |
 Soluble interleukin-2 receptor, U/mL | 762.0 (509.9–1124.0) | 655.0 (483.5–916.5) | 762.0 (576.0–1060.0)* | 1174.0 (915.0–1552.5)*# |
 Interleukin-6, pg/mL | 21.7 (7.3–53.9) | 13.1 (3.8–23.5) | 21.7 (6.3–53.9)* | 59.7 (33.5–137.4)*# |
 Interleukin-8, pg/mL | 15.5 (9.4–26.6) | 12.2 (7.8–9.0) | 15.5 (9.7–26.1)* | 26.0 (14.9–49.4)*# |
 Interleukin-10, pg/mL | 5.6 (5.00–9.4) | 5.0 (5.0–6.8) | 5.3 (5.0–8.8) | 9.5 (6.7–15.9)*# |
 Tumor necrosis factor alpha, pg/mL | 9.1 (7.2–12.1) | 8.7 (6.8–10.8) | 9.0 (7.1–11.6)* | 11.0 (8.0–14.8)*# |
 hsCRP/lymphocyte, × 10^-9 mg | 53.5 (10.5–128.1) | 10.8 (3.4–49.6) | 56.0 (15.8–115.4)* | 142.1 (82.3–300.4)*# |