Table 2 Variables associating with individual GDF15 concentrations in multivariable linear regression analysis
From: The clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults
Model with variables explaining serum GDF15 concentrations upon ICU admission | Scaled estimate (95%CI) | p value |
|---|---|---|
ICU-independent variables | ||
Age | 353 (− 528; 1234) | 0.43 |
BMI | − 674 (− 2057; 709) | 0.33 |
History of diabetes mellitus | 731 (314; 1147) | 0.0006 |
History of malignancy | 485 (60; 909) | 0.02 |
NRS score of ≥ 5 vs < 5 | 424 (− 24; 872) | 0.06 |
ICU-related variables | ||
Admission diagnosis | ||
Cardiac surgery | 16 (− 761; 793) | 0.96 |
Elective other surgery | 1566 (445; 2687) | 0.006 |
Emergency other surgery | − 1256 (− 2013; − 499) | 0.001 |
Medical disease | − 326 (− 1477; 824) | 0.57 |
APACHE-II score | 4454 (3211; 5697) | < 0.0001 |
Sepsis upon admission | 2232 (594; 3869) | 0.007 |
Infection upon admission | − 1412 (− 3059; 234) | 0.09 |
Mechanical ventilation on ICU day 1 | 296 (− 452; 1044) | 0.43 |
Steroids on ICU day 1 | 703 (212; 1194) | 0.005 |
Laboratory parameters | ||
Blood glucose upon ICU admission | − 1975 (− 4405; 455) | 0.11 |
Plasma creatinine on ICU day 1 | 22,102 (19,679; 24,526) | < 0.0001 |
Plasma total bilirubin on ICU day 1 | 13,569 (10,097; 17,041) | < 0.0001 |
Plasma CRP on ICU day 1 | − 1605 (− 3132; − 78) | 0.03 |