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Table 1 Characteristics of included studies

From: Proportional assist ventilation versus pressure support ventilation for weaning from mechanical ventilation in adults: a meta-analysis and trial sequential analysis

Authors Year Design Country Patient number Age (mean) Male (%) Mean MV (days) Mean PS Intervention 1 Intervention 2
Xirouchaki et al. [4] 2008 RCT Greece 208 60.9 (years) 66.3 4.0 APACHE II, 15.5 PAV+: initial assist 60–80%, reduced by 10–20% per hour. Extubation was performed at 10–20% assist. PSV: initial PIP 20–25 cmH2O, reduced by 2–5 cmH2O per hour. Extubation was performed at PS 10–12 cmH2O.
Sasikumar et al. [27] 2013 RCT India 23 48.6 (years) 69.6 NR APACHE II, 20.7 PAV+: the protocol for PAV+ setting was not available. PSV: the protocol for PSV setting was not available.
Elganady et al. [28] 2014 RCT Egypt 60 59.7 (years) 81.7 NR NR PAV: initial assist 70%, reduced by 10–20% every 2 h. Extubation was performed at 10–20% assist. PSV: initial PEEP 5 cmH2O, initial pressure support 5~8 cmH2O. No reduction during the trial. Extubation was performed at 120 min.
Teixeira et al. [29]* 2015 RCT Brazil 160 44.5 (years) 65.6 6.6 APACHE II, 22.7 PAV+: initial assist and the method for reduction were not available. Extubation was performed at 40% assist. PSV: pressure support with 7 cmH2O. No reduction method was mentioned. The timing for extubation was not available.
Bosma et al. [30] 2016 RCT Canada 50 64.8 (years) 50.0 5.8 APACHE II, 26.5 PAV+: initial assist 70%, reduced by the judgment of a respiratory therapist every 2 to 3 h. PSV: initial PS 15 cmH2O, reduced by the judgment of a respiratory therapist every 2 to 3 h.
Botha et al. [31] 2018 RCT Australia 50 63.2 (years) 59.2 3.4 APACHE III, 76.7; SASP, 45.5 PAV+: initial assist 70%, reduced by 10%. Extubation was performed at 30% assist. PSV: initial PS was set at patient’s need; the reduction method was not mentioned. Extubation was performed at PS 10 cmH2O.
Salama et al. [32] 2018 RCT Egypt 150 NA NA NA NA PAV+ PSV
  1. *Three-arm study