Successful ventilation of two animals with a single ventilator: individualized shared ventilator setup in an in vivo model

Table 1 Ventilator settings and measurements of in vivo individualized shared ventilation

	Individual ventilation		Shared ventilator
	Animal 1	Animal 2	Animal 1	Animal 2
Ventilator settings
Tidal volume (ml)	600	800	1400
PEEP (cmH₂O)	3	4	3	7
FiO₂	0.3	0.3	1.0
I/E ratio	1:2	1:2	1:1.5
Respiratory rate (min⁻¹)	20	20	20
Measured ventilatory values
PEEP (cmH₂O)	3	5	4	7
Ppeak vent (cmH₂O)	18	32	31
Ppeak circuit (cmH₂O)			19	18
etCO₂	31	33	32	29
Blood gas values
pH	7.54	7.54	7.47	7.49
PaO₂ (mmHg)	112	230	443	376
PaCO₂ (mmHg)	31	30	39	36
Hemodynamic values
BP (mmHg)	76/43	83/38	73/40	84/36

Table 1 shows the settings of the ventilator per animal and for the shared ventilator in a volume-controlled ventilation. In animal 2, inline PEEP was applied; in animal 1, the flow restriction with our valve was applied to distribute the pressures as desired among the two animals.

ISSN: 1364-8535