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Table 1 Effect of early tranexamic acid on all-cause mortality within 24 h of injury, after 24 h and at 28 days stratified by severity and country income level in patients randomised within 3 h of injury, excluding those with a GCS score of 3 or bilateral unreactive pupils

From: Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

  Within 24 h After 24 h At 28 days
TXA Placebo RR (95% CI) TXA Placebo RR (95% CI) TXA Placebo RR (95% CI)
n (%) n (%)   n (%) n (%)   n (%) n (%)  
All patients 112 (2.9) 147 (3.9) 0.74 (0.58–0.94) 432 (11.5) 421 (11.7) 0.98 (0.69–1.12) 544 (14.0) 568 (15.1) 0.93 (0.83–1.03)
Severity
Mild/moderate 25 (0.9) 37 (1.3) 0.66 (0.40–1.09) 163 (5.8) 186 (6.9) 0.85 (0.69–1.04) 188 (6.7) 223 (8.1) 0.82 (0.68–0.99)
Severe 87 (8.5) 110 (11.3) 0.75 (0.58–0.98) 269 (28.7) 235 (27.2) 1.05 (0.91–1.22) 356 (34.7) 345 (35.4) 0.98 (0.87–1.10)
Country income
LMIC 98 (3.3) 126 (4.4) 0.75 (0.58–0.98) 363 (12.6) 344 (12.5) 1.01 (0.88–1.16) 461 (15.5) 470 (16.3) 0.95 (0.84–1.07)
HIC 14 (1.5) 21 (2.4) 0.65 (0.33–1.26) 69 (7.7) 77 (9.0) 0.86 (0.63–1.18) 83 (9.2) 98 (11.1) 0.82 (0.62–1.08)