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Table 5 Effect of TPE on objective measures of organ dysfunction compared to controls

From: The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience

Measure

TPE (n = 40)

Standard care (n = 40)

p

Cards SOFA at time zeroa

4.0 ± 0.16

3.9 ± 0.65

0.348

Cards SOFA at 48 h

1.5 ± 1.54

2.8 ± 1.6

0.001

Lactate at time zeroa

8.1 ± 6.6

6.6 ± 4.7

0.219

Lactate at 24 h

4.8 ± 5.9 (n = 29)

6.9 ± 5.5 (n = 35)

0.145

Platelet count at time zeroa

102.6 ± 68.5

172.8 ± 72.7 (n = 37)

< 0.001

Platelet nadir

49.7 ± 36.6

73.7 ± 41.9

0.008

P/F ratio at time zeroa

176.3 ± 139.2 (n = 38)

161.8 ± 113.3 (n = 33)

0.631

P/F ratio at 48 h

217 ± 100 (n = 29)

223.6 ± 144.3 (n = 30)

0.838

Extubations

3

1

 

New intubations

0 (1 placed on ECMO)

5

 

Deaths prior to 48 h

6

9

0.568

  1. aTPE “time zero” is the time of the first TPE; standard care “time zero” is the hour of the first recorded vital signs in ICU
  2. Lactic acid measured mmol/L; platelet count measured × 1000/μL