The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience

Table 3 Primary and secondary outcomes

Outcome	TPE (n = 40)	Standard care (n = 40)	p
28-day mortality
Total study population	16 (40%)	26 (65%)	0.043
Pneumonia group	11/23 (47.8%)	15/17 (88%)	0.017
Other groups	5/17 (29.4%)	11/23 (48%)	0.332
Hospital mortality	17 (42.5%)	26 (65%)	0.072
Baseline SOFA in 48 h survivors^a	15.7 ± 3.0	13.2 ± 2.2	< 0.001
SOFA at 48 h^a	12.6 ± 4.5	12.9 ± 3.7	0.782
Change in SOFA^a	3.1 ± 2.6	0.32 ± 3.5	< 0.001
Baseline Cardiac SOFA in 48 h survivors^a	4.0 ± 0.17	3.8 ± 0.73	0.336
Cardiac SOFA at 48 h^a	1.5 ± 1.54	2.8 ± 1.6	0.001
Change in cards SOFA^a	2.47 ± 1.52	1.03 ± 1.52	< 0.001
New need for RRT during admission^b	25 (67.6%)	19 (51.4%)	0.236
Mortality associated with new RRT	12 (48%)	15 (79%)	0.06
New need for RRT at d/c in survivors	4 (30.8%)	1 (25%)	1
Net daily fluid balance preceding 24 h	4304 ± 2900	5269 ± 3629	0.244
Net daily fluid balance after 48 h	− 78 ± 1837	1466 ± 2675	0.01
Change in fluid balance	− 4382 ± 2958	− 3803 ± 4431	0.542
ICU LOS^c	16.6 ± 15.8	8.0 ± 7.4	0.003
Hospital LOS^c	24.6 ± 22.4	13.0 ± 13.2	0.006

^aFor patients who survived at least 48 h (n = 34 for the TPE arm and n = 31 for the standard arm)
^bThree ESRD in each group
^cNote that the standard care arm experienced more 28-day mortality

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