Table 1 Study population

 1. New known or suspected infection (with a chance for source control if applicable)

A. Lactic acidosis and/or failure of lactic acid clearance

 2. Multiorgan failure (≥ 2 organs failing)

B. Worsening acidosis despite adequate fluid resuscitation and/or dialysis

 3. Two or more pressors, rapidly rising pressor needs, and/or inability to wean pressors^a

C. Mottling skin appearance despite appropriate resuscitation

D. Acute drop in platelet count (± thrombocytopenia)

 Cardiogenic shock

Active metastatic malignancy

 Hemorrhagic shock

Limitations to aggressive care

 Ischemic colitis without surgery

Planned withdrawal of care

 Cardiac arrest at presentation