| Baseline BMI (kg/m2) | ||||||
---|---|---|---|---|---|---|---|
< 18.5 | 18.5 to < 20.0 | 20.0 to < 22.5 | 22.5 to < 25.0 | 25.0 to < 27.5 | 27.5 to < 30.0 | ≥ 30.0 | |
Multivariable model with no exclusions, adjusted for smoking status | |||||||
 Participants/deaths | 21,916/911 | 44,188/757 | 131,839/1133 | 145,408/850 | 101,523/492 | 46,423/262 | 20,964/125 |
 Deaths/PYs* (/1000) | 2.61 | 1.42 | 0.92 | 0.69 | 0.61 | 0.76 | 0.85 |
 HRs (95% CIs) | 3.57 (3.24–3.94) | 2.00 (1.81–2.21) | 1.33 (1.22–1.46) | 1.00 | 0.88 (0.78–0.98) | 1.07 (0.93–1.23) | 1.17 (0.96–1.41) |
Participants without known chronic diseases at baseline, adjusted for smoking status | |||||||
 Participants/deaths | 17,260/368 | 37,716/346 | 116,084/613 | 128,367/506 | 89,129/302 | 40,352/140 | 17,775/71 |
 Deaths/PYs* (/1000) | 1.30 | 0.74 | 0.55 | 0.46 | 0.42 | 0.46 | 0.56 |
 HRs (95% CIs) | 2.60 (2.26–2.99) | 1.56 (1.36–1.80) | 1.19 (1.06–1.34) | 1.00 | 0.92 (0.80–1.06) | 0.99 (0.81–1.19) | 1.17 (0.91–1.51) |
Participants without known chronic diseases at baseline, adjusted for smoking status, and excluding the first 3 years of follow-up (primary prespecified analysis) | |||||||
 Participants/deaths | 16,701/280 | 36,957/288 | 114,513/513 | 126,914/425 | 88,193/271 | 39,922/118 | 17,563/62 |
 Deaths/PYs* (/1000) | 1.44 | 0.90 | 0.66 | 0.55 | 0.53 | 0.54 | 0.69 |
 HRs (95% CIs) | 2.42 (2.07–2.84) | 1.59 (1.36–1.85) | 1.21 (1.06–1.38) | 1.00 | 0.97 (0.83–1.13) | 0.98 (0.80–1.21) | 1.22 (0.93–1.60) |
Never smokers without known chronic diseases at baseline, excluding the first 3 years of follow-up | |||||||
 Participants/deaths | 10,354/93 | 21,524/109 | 70,419/219 | 81,426/194 | 56,428/137 | 26,190/68 | 12,597/42 |
 Deaths/PYs* (/1000) | 0.80 | 0.63 | 0.47 | 0.38 | 0.39 | 0.41 | 0.55 |
 HRs (95% CIs) | 2.02 (1.57–2.60) | 1.61 (1.27–2.04) | 1.26 (1.04–1.53) | 1.00 | 1.02 (0.82–1.28) | 1.07 (0.81–1.41) | 1.39 (0.99–1.95) |