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Table 2 Primary outcome and cause analysis

From: High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial

 

HFNC (n = 44)

NIV (n = 42)

Risk difference, % (95% CI)

p value

Primary outcome, n (%)

 Treatment failure

10 (22.7)

12 (28.6)

− 5.8 (− 23.8 to 12.4)

0.535

  Invasive ventilation

6 (13.6)

6 (14.29)

− 0.65 (− 16.01 to 14.46)

0.931

  Treatment switch

4 (9.1)

6 (14.3)

− 5.2 (− 19.82 to 9.05)

0.516

Analysis of treatment failure, n (%)

 Treatment intolerance

0/10 (0)

6/12 (50.0)

− 50.0 (− 74.62 to − 12.9)

0.015

 Aggravation of respiratory distress

5/10 (50)

2/12 (16.67)

33.33 (− 5.21 to 62.27)

0.172

 Aggravation of hypoxemia

2/10 (20)

1/12 (8.33)

11.67 (− 18.95 to 43.4)

0.571

 Aggravation of carbon dioxide retention

3/10 (30)

3/12 (25)

5 (− 29.15 to 39.33)

1.0

  1. HFNC high-flow nasal cannula oxygen therapy, NIV non-invasive ventilation