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Table 3 ECCO2R weaning protocol for patients with ARDS

From: ECCO2R therapy in the ICU: consensus of a European round table meeting

Weaning criteria and steps for weaning for ECCO2R in ARDS*

ECCO2R will be applied for at least 48 h

PaO2/FiO2 > 200 mmHg before testing weaning possibility

Set VT at 6 mL/PBW and PEEP 5–10 cmH2O

Driving pressure should be < 14 cmH2O

Respiratory rate should be 20–30 breaths/min

Reduce gas flow to zero, using 2 L/min decremental steps

While weaning, pH should remain > 7.30 and respiratory rate < 25 breaths/min

Patient will be weaned off ECCO2R therapy after a minimum of 12 h of stability under these settings (including pH > 7.30 and respiratory rate < 25 breaths/min)

  1. *A consensus was reached for all of these criteria and steps