From: Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients
All patients (n = 140) | No delirium and normal neurological examination (N = 22) | Delirium and/or abnormal neurological examination (N = 118) | p | |
---|---|---|---|---|
Age - median [IQR] | 62 [52; 70] | 65 [48; 71] | 62 [52; 71] | 0.302 |
Male (n, %) | 100 (71.4) | 11 (50.0) | 89 (75.4) | 0.015 |
Medical history | ||||
Neurological medical history (n, %) | 22 (15.7) | 4 (18.1) | 18 (15.3) | 0.707 |
Stroke/transient ischemic attack | 9 (6.4) | 0 (0.0) | 9 (8.0) | 0.354 |
Partial epilepsy | 2 (1.4) | 0 (0.0) | 2 (1.8) | 1 |
Mild cognitive alteration | 4 (2.9) | 1 (4.5) | 3 (2.7) | 0.499 |
Migraine | 5 (3.6) | 1 (4.5) | 4 (3.4) | 0.580 |
Trauma brain injury | 2 (1.4) | 1 (4.5) | 1 (0.9) | 0.291 |
Aneurysm | 1 (0.7) | 1 (4.5) | 0 (0.0) | 0.157 |
Cardiovascular diseases—n(%) | 70 (50.0) | 12 (54.5) | 58 (49.2) | 0.642 |
Malignancies/hemopathies—n(%) | 21 (15.0) | 5 (22.7) | 16 (13.6) | 0.423 |
Immune diseases—n(%) | 4 (2.9) | 2 (9,1) | 2 (1.7) | 0.233 |
Diabetes—n(%) | 21 (15.0) | 3 (13.6) | 18 (15.3) | 1 |
Chronic liver disease—n(%) | 2 (1.4) | 0 (0.0) | 2 (1.7) | 1 |
Chronic renal disease—n(%) | 9 (6.4) | 3 (13.6) | 6 (5.1) | 0.300 |
Respiratory disease—n(%) | 22 (15.7) | 2 (9,1) | 20 (16.9) | 0.566 |
Chronic obstructive pulmonary disease | 2 (1.4) | 0 (0.0) | 2 (1.7) | 1 |
Asthma | 5 (3.6) | 1 (4.5) | 4 (3.4) | 1 |
Obstructive sleep apnea | 16 (11.4) | 1 (4.5) | 15 (12.7) | 0.482 |
SAPS II—median [IQR] | 49 [37; 64] | 51 [34; 61] | 49 [38; 63] | 0.647 |
SOFA—median [IQR] | 7 [4; 8] | 6 [4; 8] | 7 [5; 8] | 0.486 |
Antiviral treatments—n(%) | ||||
Lopinavir + ritonavir | 46 (32.9) | 5 (22.7) | 41 (34.7) | 0.271 |
Remdesivir | 11 (7.9) | 0 (0.0) | 11 (9.3) | 0.282 |
Hydroxychloroquine/azithromycine | 52 (37.1) | 8 (36.4) | 44 (37.3) | 0.934 |
Tocilizumab | 3 (2.1) | 1 (4.5) | 2 (1.7) | 0.807 |
Anakinra | 1 (0.7) | 0 (0.0) | 1 (0.8) | 1 |
Dexamethasone | 1 (0.7) | 0 (0.0) | 1 (0.8) | 1 |
None | 25 (17.9) | 7 (31.8) | 18 (15.3) | 0.130 |
Positive SARS-CoV-2 RT-PCR in nasopharyngeal swabs | 140 (100) | 22 (100) | 118 (100) | 1 |
Chest CT scan suggestive of SARS-CoV-2 infection | 139 (99.3) | 21 (95.5) | 118 (100) | 0.157 |