Fig. 1
From: ACEI/ARB therapy in COVID-19: the double-edged sword of ACE2 and SARS-CoV-2 viral docking
Model for engagement of renin-angiotensin-aldosterone system with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus binds angiotensin-converting enzyme (ACE) 2 (ACE2), promoting internalization of the viral receptor. ACE2-dependent production of angiotensin-(1-7) is disrupted, and production of angiotensin II-(1-8) increases. Changes in angiotensin levels alter the target receptor activity in select tissues. Major organs for gene expression are represented with images, and sites for secondary expression are listed in parentheses. Underlining indicates that the data are from only cell-line analysis. AGT indicates angiotensinogen; AT1, angiotensin II type 1 receptor; AT2, angiotensin II type 2 receptor; CoV-2, coronavirus 2; COVID-19, coronavirus disease 2019; MAS, mitochondrial assembly; TMPRSS2, transmembrane serine protease 2. Expression data were sourced from the Human Protein Atlas (https://www.proteinatlas.org); organ icons made by Vitaly Gorbachev, Smashicons, Prettycons, and Freepik from www.flaticon.com