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Table 1 Study characteristics

From: Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis

First author (Year) Study design City (country) Male (%) Age (median, years) Settings PE diagnosis D-dimer (median, mg/dL) Prophylactic anticoagulation (%) Mechanical ventilation (%) ARDS (%) Overall mortality (%)
Asia
 Wang Y (2020) [2] RCT (remdesivir group) Beijing (China) 56 66 Inpatient NA NA NA 7 10 15
 Wang Y (2020) [2] RCT (placebo group) Beijing (China) 65 64 Inpatient NA NA NA 13 8 13
America
 Riker RR (2020) [3] Case series Portland (USA) NA NA Inpatient (ICU) CTPA NA NA 100 100 NA
 LeBrun DG (2020) [4] Retrospective cohort New York (USA) 33 87* Inpatient (ICU, ward) NA NA NA 33 NA 56
Europe
 Wichmann D (2020) [5] Case series Hamburg (Germany) 75 73 Mortuary Autopsy 90.4 33 33 NA 100
 Klok FA (2020) [6] Retrospective cohort Leiden (Netherlands) 76 64* Inpatient (ICU) CTPA NA 100 NA NA 22
 Llitjos JF (2020) [7] Retrospective cohort Pairs (France) 77 68 Inpatient (ICU) CDU 1.8 31 100 81 12
 Helms J (2020) [8] Prospective cohort Strasbourg (France) 81 63 Inpatient (ICU) CTPA 2.3 100 100 100 9
 Menter T (2020) [9] Retrospective cohort Basel (Switzerland) 81 76* Mortuary Autopsy 4.0 NA 30 NA 100
 Florian Bompard (2020) [10] Retrospective cohort Paris (France) 70 64 Inpatient, outpatient CTPA 1.6 53 13 NA 12
 Hékimian G (2020) [11] Retrospective cohort Paris (France) NA NA Inpatient (ICU) CTPA or autopsy NA NA NA NA NA
 Artifoni M (2020) [12] Retrospective cohort Nantes (France) 61 64 Inpatient (ICU, ward) CTPA 0.8 99 11 NA NA
 Fraissé M (2020) [13] Retrospective cohort Argenteuil (France) 79 61 Inpatient (ICU) CDU 2.4 47 89 NA 41
 Thomas W (2020) [14] Retrospective cohort Cambridge (UK) 69 20–29: 2%
30–39: 5%
40–49: 13%
50–59: 29%
60–69: 22%
70–79: 27%
80–89: 3%
Inpatient (ICU) CTPA 0.4 NA 83 NA 16
 Lodigiani C (2020) [15] Retrospective cohort Milano (Italy) 68 66 Inpatient (ICU, ward) CTPA Survivors:
Day 1–3: 0.4
Day 4–6: 0.4
Day 7–9: 0.5
Non-survivors:
Day 1–3: 0.9
Day 4–6: 0.9
Day 7–9: 1.5
79 NA NA 26
 Poissy J (2020) [16] Case series Lille (France) NA NA Inpatient (ICU) CTPA NA NA 63 63 14
 Gervaise A (2020) [17] Retrospective cohort Saint Mande Cedex (France) 75 62* Outpatient CTPA 3.6* NA 57 NA 15
 Longchamp A (2020) [18] Case series Sion (Switzerland) 64 68* Inpatient CTPA 2.1 96 92 NA 20
 Leonard-Lorant I (2020) [19] Retrospective cohort Strasbourg (France) 66 64 Inpatient (ICU, ward) CTPA PE: 15.4
Non-PE: 1.9
46 NA NA NA
 Grillet F (2020) [20] Retrospective cohort Besancon (France) 70 66* Inpatient (ICU, ward) CTPA NA NA 34 NA NA
  1. *In studies not reporting the median, results are represented by the mean
  2. CDU complete duplex ultrasound, CTPA CT pulmonary angiography, ICU intensive care unit, NA not available, PE pulmonary embolism, RCT randomized controlled trial