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Table 1 The resultant changes in ventilator/ECMO settings and blood gas analysis before and after PP

From: Prone positioning under VV-ECMO in SARS-CoV-2-induced acute respiratory distress syndrome

Variables Before prone position After prone position P value
Mechanical ventilation settings
 Tidal volume (mL/kg) 2.4 (1.8–2.9) 2.4 (1.8–2.7) 0.42
 RR (breaths/min) 20 (16–25) 19 (16–25) 0.87
 Plateau airway pressure (cmH2O) 28 (26–32) 29 (28–32) 0.43
 PEEP (cmH2O) 14 (12–18) 16 (12–20) 0.36
 Respiratory system compliance (mL/cmH2O) 18.6 (13.7–25.9) 17.9 (12.8–26.5) 0.92
 Driving pressure (cmH2O) 14.5 (12–16.5) 14.5 (11–16) 0.56
 Inspired fraction of oxygen (%) 70 (60–100) 67.5 (52.5–95) 0.16
ECMO settings
 ECMO blood flow (L/min) 6.2 (6–6.7) 6 (5.8–6.7) 0.41
 Sweep gas flow (L/min) 7 (6–8.5) 7 (6.8–9) 0.15
 FDO2 (%) 100 (80–100) 100 (80–100) 0.56
Gas analysis
 PaO2 (mmHg) 64 (51–78) 82 (66–109) 0.007
 PaO2/FiO2 (mmHg) 84 (73–108) 112 (83–157) 0.002
 PaCO2 (mmHg) 44 (41–46) 42 (36–49) 0.27
 pH 7.38 (7.35–7.43) 7.38 (7.34–7.42) 0.47
  1. Data are expressed as number (%) or median [IQR]. Analyses were performed with the GraphPad Prism 6 software (San Diego, CA). All tests were two-tailed, with α level at 0.05. The comparisons before vs. after prone position were realized by Wilcoxon matched-pairs signed-rank test
  2. RR respiratory rate, PEEP positive end-expiratory pressure, FiO2 fraction of inspired oxygen, PaCO2 arterial partial pressure of carbon dioxide, PaO2 arterial partial pressure of oxygen, FDO2 fraction on oxygen delivered in the sweep gas, ECMO extracorporeal membrane oxygenation