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Table 1 Baseline characteristics, therapeutic interventions, and outcomes of patients, according to respiratory compliance

From: Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19

  Overall (N = 36), no. (%) of patientsa High respiratory compliance (N = 17), no. (%) of patientsa Low respiratory compliance (N = 19), no. (%) of patientsa P value between groups
Baseline characteristics     
 Age, mean ± SD, years 53.4 ± 10.2 56.1 ± 7.1 50.9 ± 12.1 0.12
 Male sex 30 (83.3) 16 (94.1) 14 (73.7) 0.18
 Obesityb 14 (38.9) 3 (17.7) 11 (57.9) 0.02
 Diabetes mellitus 11 (30.6) 5 (29.4) 6 (31.6) 1.0
 Arterial hypertension 16 (44.4) 11 (64.7) 5 (26.3) 0.19
 SAPS 2 score, median [IQR] 31 [27–36] 31 [29–36] 29 [22–39] 0.51
 SOFA score, median [IQR] 5 [4–7] 6 [4–7] 4 [3–6] 0.04
 Tidal volume, mean ± SD, mL/kg 6.1 ± 0.6 6.2 ± 0.3 6.0 ± 0.7 0.02
 Respiratory frequency, median [IQR], breaths/min 25 [24–27] 25 [24–26] 26 [24–28] 0.64
 FiO2, median [IQR], % 65 [50–100] 60 [40–80] 70 [60–100] 0.07
 PaO2/FiO2 ratio, median [IQR] 152 [112–240] 209 [150–256] 117 [83–201] 0.02
 PEEP, mean ± SD, cmH2O 13.4 ± 3.2 13.4 ± 3.6 13.4 ± 3.1 0.92
 Respiratory compliance, mean ± SD, mL/cmH2Oc 39.4 ± 16.9 51.8 ± 16.4 28.3 ± 6.1  
Therapeutic interventions     
 Prone positioning 29 (80.6) 12 (70.6) 17 (89.5) 0.22
 Number of sessions, median [IQR] 4.0 [2.0–6.0] 4.0 [2.5–5.0] 5.0 [1.7–6.0] 0.91
 Inhaled nitric oxide 9 (25.0) 2 (11.8) 7 (36.8) 0.13
 Venovenous ECMO 7 (19.4) 0 (0.0) 7 (36.8) 0.008
 Vasopressors 31 (86.1) 17 (100.0) 14 (73.7) 0.048
 Renal replacement therapy 7 (19.4) 3 (17.7) 4 (21.1) 1.0
 Hydroxychloroquine 32 (88.9) 16 (94.1) 16 (84.2) 0.6
 Steroïds 11 (30.6) 5 (29.4) 6 (31.6) 1.0
Outcomes
 Ventilator-free days, median [IQR] 3.0 [0.0–14.5] 10.0 [0.0–17.2] 0.0 [0.0–8.0] 0.04
 Mortality at day 28 4 (11.1) 1 (5.9) 3 (15.8) 0.61
  1. Abbreviations: ECMO extracorporeal membrane oxygenation, FiO2 fraction of inspired oxygen, PEEP positive end-expiratory pressure
  2. aUnless otherwise indicated
  3. bObesity is defined by a body mass index above 30 kg/m2. The formula for body mass index is weight in kilograms divided by height in meters squared
  4. cNo statistical comparison performed