Skip to main content

Table 1 Baseline characteristics, therapeutic interventions, and outcomes of patients, according to respiratory compliance

From: Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19

 

Overall (N = 36), no. (%) of patientsa

High respiratory compliance (N = 17), no. (%) of patientsa

Low respiratory compliance (N = 19), no. (%) of patientsa

P value between groups

Baseline characteristics

    

 Age, mean ± SD, years

53.4 ± 10.2

56.1 ± 7.1

50.9 ± 12.1

0.12

 Male sex

30 (83.3)

16 (94.1)

14 (73.7)

0.18

 Obesityb

14 (38.9)

3 (17.7)

11 (57.9)

0.02

 Diabetes mellitus

11 (30.6)

5 (29.4)

6 (31.6)

1.0

 Arterial hypertension

16 (44.4)

11 (64.7)

5 (26.3)

0.19

 SAPS 2 score, median [IQR]

31 [27–36]

31 [29–36]

29 [22–39]

0.51

 SOFA score, median [IQR]

5 [4–7]

6 [4–7]

4 [3–6]

0.04

 Tidal volume, mean ± SD, mL/kg

6.1 ± 0.6

6.2 ± 0.3

6.0 ± 0.7

0.02

 Respiratory frequency, median [IQR], breaths/min

25 [24–27]

25 [24–26]

26 [24–28]

0.64

 FiO2, median [IQR], %

65 [50–100]

60 [40–80]

70 [60–100]

0.07

 PaO2/FiO2 ratio, median [IQR]

152 [112–240]

209 [150–256]

117 [83–201]

0.02

 PEEP, mean ± SD, cmH2O

13.4 ± 3.2

13.4 ± 3.6

13.4 ± 3.1

0.92

 Respiratory compliance, mean ± SD, mL/cmH2Oc

39.4 ± 16.9

51.8 ± 16.4

28.3 ± 6.1

 

Therapeutic interventions

    

 Prone positioning

29 (80.6)

12 (70.6)

17 (89.5)

0.22

 Number of sessions, median [IQR]

4.0 [2.0–6.0]

4.0 [2.5–5.0]

5.0 [1.7–6.0]

0.91

 Inhaled nitric oxide

9 (25.0)

2 (11.8)

7 (36.8)

0.13

 Venovenous ECMO

7 (19.4)

0 (0.0)

7 (36.8)

0.008

 Vasopressors

31 (86.1)

17 (100.0)

14 (73.7)

0.048

 Renal replacement therapy

7 (19.4)

3 (17.7)

4 (21.1)

1.0

 Hydroxychloroquine

32 (88.9)

16 (94.1)

16 (84.2)

0.6

 Steroïds

11 (30.6)

5 (29.4)

6 (31.6)

1.0

Outcomes

 Ventilator-free days, median [IQR]

3.0 [0.0–14.5]

10.0 [0.0–17.2]

0.0 [0.0–8.0]

0.04

 Mortality at day 28

4 (11.1)

1 (5.9)

3 (15.8)

0.61

  1. Abbreviations: ECMO extracorporeal membrane oxygenation, FiO2 fraction of inspired oxygen, PEEP positive end-expiratory pressure
  2. aUnless otherwise indicated
  3. bObesity is defined by a body mass index above 30 kg/m2. The formula for body mass index is weight in kilograms divided by height in meters squared
  4. cNo statistical comparison performed