Skip to main content

Table 1 Baseline characteristics of the patients and respiratory mechanics (n = 16)

From: Transpulmonary pressure in SARS-CoV-2-associated acute respiratory distress syndrome: a single-center observational study

Characteristics  
 Male, n (%) 11 (69)
 Age (years) 70 (61–72)
 Body mass index (kg/m2) 29 (26–31)
 Organ failure at baseline (SOFA), n (%)
  Hemodynamic 12 (75)
  Renal 4 (25)
  Hepatic 2 (13)
  Hematological 1 (6)
 Arterial blood gas
  PaO2/FiO2 ratio 170 (150–208)
  pH 7.43 (7.38–7.47)
  PaO2 (mmHg) 71 (62–89)
  PaCO2 (mmHg) 40 (37–45)
  Lactates (mmol/l) 1.2 (1–1.4)
 Radiologic characteristics, n (%)
  Bilateral pneumonia 4 (25)
  Multiple mottling and ground-glass opacity 12 (75)
 Time between admission and intubation (day) 2 (2–3)
Respiratory mechanics at day 1
 Tidal volume (ml/kg PBW) 7 (6.6–7.3)
 Respiratory rate (beats/min) 22 (20–24)
 PEEPtot,rs (cm H2O) 10 (10–13)
 PEEPtot,es (cm H2O) 8 (8–12)
 PEEPtot,L (cm H2O) 2 (−1–3)
 Pplat,rs (cm H2O) 19 (18–22)
 Pplat,es (cm H2O) 13 (11–16)
 Pplat,L (cm H2O) 6 (6–11)
 DP,rs (cm H2O) 9 (6–12)
 DP,cw (cm H2O) 5 (3–5)
 DP,L (cm H2O) 4 (2–9)
 Est,rs (cm H2O/L) 23 (18–30)
 Est,cw (cm H2O/L) 4 (4–10)
 Est,L (cm H2O/L) 19 (8–20)
  1. Results are expressed as median (IQR) or as number of patients (percentage) as appropriate
  2. PBW, predicted body weight; SOFA, sepsis-related organ failure; PEEPtot,rs, static end-expiratory pressure of the respiratory system; PEEPtot,es, static end-expiratory esophageal pressure; PEEPtot,L, static end-expiratory transpulmonary pressure; Pplat,rs, static end-inspiratory pressure of the respiratory system; Pplat,es, static end-inspiratory esophageal pressure; Pplat,L, static end-inspiratory transpulmonary pressure; DP,rs, DP,cw, DP,L, driving pressure of respiratory system, chest wall, and lung, respectively; Est,rs, Est,cw, Est,L, static elastance of respiratory system, chest wall, and lung, respectively