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Table 1 Baseline characteristics of the patients and respiratory mechanics (n = 16)

From: Transpulmonary pressure in SARS-CoV-2-associated acute respiratory distress syndrome: a single-center observational study

Characteristics

 

 Male, n (%)

11 (69)

 Age (years)

70 (61–72)

 Body mass index (kg/m2)

29 (26–31)

 Organ failure at baseline (SOFA), n (%)

  Hemodynamic

12 (75)

  Renal

4 (25)

  Hepatic

2 (13)

  Hematological

1 (6)

 Arterial blood gas

  PaO2/FiO2 ratio

170 (150–208)

  pH

7.43 (7.38–7.47)

  PaO2 (mmHg)

71 (62–89)

  PaCO2 (mmHg)

40 (37–45)

  Lactates (mmol/l)

1.2 (1–1.4)

 Radiologic characteristics, n (%)

  Bilateral pneumonia

4 (25)

  Multiple mottling and ground-glass opacity

12 (75)

 Time between admission and intubation (day)

2 (2–3)

Respiratory mechanics at day 1

 Tidal volume (ml/kg PBW)

7 (6.6–7.3)

 Respiratory rate (beats/min)

22 (20–24)

 PEEPtot,rs (cm H2O)

10 (10–13)

 PEEPtot,es (cm H2O)

8 (8–12)

 PEEPtot,L (cm H2O)

2 (−1–3)

 Pplat,rs (cm H2O)

19 (18–22)

 Pplat,es (cm H2O)

13 (11–16)

 Pplat,L (cm H2O)

6 (6–11)

 DP,rs (cm H2O)

9 (6–12)

 DP,cw (cm H2O)

5 (3–5)

 DP,L (cm H2O)

4 (2–9)

 Est,rs (cm H2O/L)

23 (18–30)

 Est,cw (cm H2O/L)

4 (4–10)

 Est,L (cm H2O/L)

19 (8–20)

  1. Results are expressed as median (IQR) or as number of patients (percentage) as appropriate
  2. PBW, predicted body weight; SOFA, sepsis-related organ failure; PEEPtot,rs, static end-expiratory pressure of the respiratory system; PEEPtot,es, static end-expiratory esophageal pressure; PEEPtot,L, static end-expiratory transpulmonary pressure; Pplat,rs, static end-inspiratory pressure of the respiratory system; Pplat,es, static end-inspiratory esophageal pressure; Pplat,L, static end-inspiratory transpulmonary pressure; DP,rs, DP,cw, DP,L, driving pressure of respiratory system, chest wall, and lung, respectively; Est,rs, Est,cw, Est,L, static elastance of respiratory system, chest wall, and lung, respectively