Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study

Table 4 Independent risk factors of 28-day mortality and nomogram score

Factors		Multivariable HR (95% CI)	P value	Nomogram score
Age, years#		1.05 (1.03–1.07)	< 0.001	(Age-20) × 1.25
NLR	> 8.0	2.63 (1.55–4.40)	< 0.001	26.60
NLR	≤ 8.0	1 (ref)		0
Direct bilirubin, μmol/L	> 5.0	1.77 (1.15–2.76)	0.010	16.06
Direct bilirubin, μmol/L	≤ 5.0	1 (ref)		0
LDH level, U/L	> 360	11.77 (5.62–24.65)	< 0.001	67.63
LDH level, U/L	≤ 360	1 (ref)		0

# per 1 unit increase
HR hazard ratio, ref reference, NLR neutrophil-to-lymphocyte ratio, LDH lactate dehydrogenase, CI confidence interval

ISSN: 1364-8535