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Table 2 Multivariate analysis of variables associated with C. difficile infection (CDI) in patients with enteral nutrition (EN) admitted to ICU

From: Risk factors and intestinal microbiota: Clostridioides difficile infection in patients receiving enteral nutrition at Intensive Care Units

Model Variables Multivariable analysis
OR (95% CI) P value
Initial model Age, years 1.020 (0.960–1.083) 0.528
  Duration of hospitalization (days) 1.011 (0.992–1.030) 0.262
  Surgical intervention in previous 6 months 0.798 (0.201–3.179) 0.749
  CCI 1.066 (0.645–1.762) 0.803
  Metabolic disorders 1.047 (0.292–3.750) 0.944
  History of cerebral infarction 5.049 (0.978–26.071) 0.053
  Leukocyte count (×109 /L) 1.010 (0.918–1.111) 0.836
  Serum albumin (g/L) 0.977 (0.883–1.080) 0.649
  PPI use 0.728 (0.102–5.207) 0.752
  Carbapenems 2.532 (0.582–11.014) 0.215
  Metronidazole 0.321 (0.091–1.135) 0.078
Final model History of cerebral infarction 9.759 (2.140–44.498) 0.003**
  Metronidazole 0.287 (0.091–0.902) 0.033*
  1. Abbreviations: OR odds ratios, CI confidence interval, CCI Charlson comorbidities index, PPI proton pump inhibitor
  2. *P < 0.05; ** P< 0.01