Risk factors and intestinal microbiota: Clostridioides difficile infection in patients receiving enteral nutrition at Intensive Care Units

Table 2 Multivariate analysis of variables associated with C. difficile infection (CDI) in patients with enteral nutrition (EN) admitted to ICU

Model	Variables	Multivariable analysis
Model	Variables	OR (95% CI)	P value
Initial model	Age, years	1.020 (0.960–1.083)	0.528
	Duration of hospitalization (days)	1.011 (0.992–1.030)	0.262
	Surgical intervention in previous 6 months	0.798 (0.201–3.179)	0.749
	CCI	1.066 (0.645–1.762)	0.803
	Metabolic disorders	1.047 (0.292–3.750)	0.944
	History of cerebral infarction	5.049 (0.978–26.071)	0.053
	Leukocyte count (×10⁹ /L)	1.010 (0.918–1.111)	0.836
	Serum albumin (g/L)	0.977 (0.883–1.080)	0.649
	PPI use	0.728 (0.102–5.207)	0.752
	Carbapenems	2.532 (0.582–11.014)	0.215
	Metronidazole	0.321 (0.091–1.135)	0.078
Final model	History of cerebral infarction	9.759 (2.140–44.498)	0.003^**
	Metronidazole	0.287 (0.091–0.902)	0.033^*

Abbreviations: OR odds ratios, CI confidence interval, CCI Charlson comorbidities index, PPI proton pump inhibitor
*P < 0.05; ** P< 0.01

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