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Table 4 Virological findings on admission and on day 7

From: Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis

  Total Standard of care Lopinavir/ritonavir Hydroxy-chloroquine p value
Respiratory RT-PCR at admission
 Patients, n 80 22 20 38
 Samples analyzed, n (%) 67 (84) 21 (95) 13 (65) 33 (87)
 CT value 25 (23–30) 26 (24–31) 25 (23–30) 24 (21–29) 0.498
Plasma RT-PCR at admission
 Patients, n 80 22 20 38
 Samples analyzed, n (%) 23 (29) 5 (23) 3 (15) 15 (39)
 Negative RT-PCR, n (%) 11 (48) 4 (80) 0 (0) 7 (47) 0.09
 Positive RT-PCR, n (%) 12 (52) 1 (20) 3 (15) 8 (53)  
 CT value 30 (29–33) 35 (35–35) 30 (29–31) 30 (29–32) NA*
Respiratory RT-PCR at day 7
 Patients, n 80 22 20 38
 Samples analyzed, n (%) 51 (64) 14 (64) 11 (55) 26 (68)
 Negative RT-PCR, n (%) 14 (27) 2 (14) 5 (45) 7 (27) 0.222
 Positive RT-PCR, n (%) 37 (73) 12 (86) 6 (55) 19 (73)  
 CT value 29 (27–34) 28 (27–32) 29 (25–29) 32 (28–35) 0.514
Plasma RT-PCR at day 7
 Patients, n 80 22 20 38
 Samples analyzed, n (%) 54 (68) 13 (59) 13 (65) 28 (74)
 Negative RT-PCR, n (%) 42 (78) 11 (85) 9 (69) 22 (79) 0.634
 Positive RT-PCR, n (%) 12 (22) 2 (15) 4 (31) 6 (21)  
 CT value 32 (30–36) 38 (38–38) 31 (30–32) 32 (29–34) 0.237
  1. Categorical variables are expressed as absolute value (%) and continuous variables as median (IQR)
  2. IQR interquartile range, RT-PCR reverse transcription polymerase chain reaction, CT cycle threshold
  3. *NA because the number of samples analyzed was to low (n < 2)