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Table 1 Characteristics of study participants (n = 159)

From: Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia

 

Overall n = 159

CAP n = 54

HAP n = 68

VAP n = 37

Clinical features

 Admission ward

  Intensive care unit

129 (81)

41 (76)

51 (75)

37 (100)

  Surgical unit

13 (8)

1

12 (18)

–

  Medical unit

12 (7)

7 (13)

5 (7)

–

  Emergency room

5 (4)

5 (9)

–

–

 Demographics

  Age, years

63 [55–72]

64 [55–74]

64 [56–71]

61 [53–69]

  Male

107 (67)

32 (59)

46 (67)

29 (78)

 Comorbid conditions

  Immune suppressiona

52 (33)

11 (20)

29 (43)

12 (32)

  Chronic pulmonary conditionsb

52 (33)

19 (35)

26 (38)

7 (19)

  Charlson score

2 [1–5]

2 [1–4]

3 [1–6]

2 [1–5]

 Severity of disease at inclusion

  SOFA score (in ICU patients)

6 [4–9]

6 [4–9]

6 [4–9]

6 [4–8]

  Septic shock

49 (31)

13 (24)

18 (27)

18 (49)

  Initiation of respiratory support

64 (40)

20 (37)

34 (50)

–

  In-hospital death

45 (28)

14 (26)

13 (19)

18 (49)

Type of microbiological sampling

 Endotracheal aspiration

71 (45)

30 (55)

33 (49)

8 (22)

 Sputum

33 (21)

13 (24)

20 (29)

–

 Bronchoalveolar lavage

34 (21)

4 (7)

13 (19)

17 (46)

 Blind bronchial sampling

21 (13)

7 (13)

2 (3)

12 (32)

Microbiology—conventional techniques

Escherichia coli

17 (11)

4 (7)

5 (7)

8 (22)

Pseudomonas aeruginosa

15 (9)

3 (6)

8 (12)

4 (11)

Staphylococcus aureus

15 (9)

3 (6)

4 (6)

8 (22)

Klebsiella pneumoniae group

10 (6)

2 (4)

5 (7)

3 (8)

Haemophilus influenzae

10 (6)

4 (7)

4 (6)

2 (5)

Streptococcus pneumoniae

6 (4)

3 (6)

3 (4)

–

Enterobacter cloacae complex

7 (4)

1

5 (7)

1 (3)

Enterobacter aerogenes

4 (3)

1

2 (3)

1

Citrobacter freundii

2 (1)

–

2 (3)

–

Serratia marcescens

2 (1)

–

1

1

Morganella morganii

2 (1)

–

–

2 (5)

Raoultella

2 (1)

1

–

1

Stenotrophomonas maltophilia

2 (1)

–

–

2 (5)

Acinetobacter calcoaceticus-baumannii complex

1

–

–

1

Legionella pneumophila

1

1

–

–

  1. Results are presented as n (%) or median [interquartile range]
  2. Conventional techniques include culture for all pathogens presented, apart from Legionella pneumophila which was detected using molecular techniques. Only pathogens cultured at pre-defined levels are presented (≥ 103 CFU/ml for blind bronchial sampling, ≥ 104 CFU/ml for bronchoalveolar lavage, ≥ 105 CFU/ml for endotracheal aspiration, and ≥ 107 CFU/ml for sputum samples)
  3. aImmunosuppression was defined as leucopenia < 1 Giga/L, HIV infection, history of solid organ or stem cell transplantation, and immunosuppressive treatment including corticosteroids over 10 mg/day of equivalent prednisone for more than 15 days
  4. bChronic pulmonary condition included patients with history of chronic obstructive pulmonary disease, severe bronchiectasis, cystic fibrosis, and chronic respiratory insufficiency
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Critical Care

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