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Table 3 Characteristics of ARDS patients treated with invasive ventilation and use of adjunctive by severity category

From: Incidence and outcomes of acute respiratory distress syndrome in intensive care units of mainland China: a multicentre prospective longitudinal study

Parameter

ARDS

Mild

Moderate

Severe

P valueb

n = 527

n = 51

n = 250

n = 226

 

D1 IPPV

299 (56.7)

25 (49.0)

125 (50.0)

149 (65.9)

0.001

IPPV during ICU

400 (75.9)

30 (58.8)

177 (70.8)

193 (85.4)

0.000

Mode on 1st day of IPPV

 Volume control ventilation

55 (13.8)

3 (10.0)

22 (12.4)

30 (13.8)

 

 Pressure control ventilation

192 (48.0)

11 (36.7)

81 (45.8)

100 (51.8)

 

 SIMV+PS

47 (11.8)

4 (13.3)

18 (10.2)

25 (13.0)

 

 Pressure support ventilation

70 (17.5)

7 (23.3)

36 (20.3)

27 (14.0)

 

 Bilevel

32 (8.0)

5 (16.7)

18 (10.2)

9 (4.7)

 

 Other modes

4 (1.0)

0 (0.0)

2 (1.1)

2 (1.0)

 

PEEP median (IQR), cmH2O

8 (6–12)

7 (5–8)

8 (6–10)

10 (6–12)

0.000

VT, median (IQR) (ml/kg PBW)

6.8 (5.8–7.9)

7.0 (6.6–7.7)

6.8 (5.9–8.0)

6.8 (5.8–7.9)

0.538

Plateau pressure, median (IQR), cmH2O

20 (16–26)

20 (15–23)

20 (15–25)

22 (18–27)

0.220

Driving pressurea, median (IQR), cmH2O

12 (8–16)

14 (10–15)

13 (8–16)

12 (8–17)

0.779

Airway resistancea, median (IQR) cmH2O/L/S

12.0 (8.0–18.2)

12.0 (9.7–17.0)

11.0 (7.8–19.0)

12.0 (8.0–18.0)

0.571

Compliancea, median (IQR) ml/cmH2O

35.0 (25.0–43.7)

36.4 (30.7–43.0)

36.4 (24.0–52.0)

32.0 (25.0–42.0)

0.191

ABG, D1 ARDS

 PaO2/FIO2, median (IQR), mmHg

113 (80–161)

227 (206–270)

142 (115–166)

78 (59–96)

0.000

 PaCO2, median (IQR), mmHg

36.3 (31.2–42.7)

36.2 (29.6–39.0)

35.9 (31.0–41.5)

37.2 (31.8–45.2)

0.044

 pH, median (IQR)

7.42 (7.36–7.46)

7.43 (7.36–7.48)

7.2 (7.36–7.46)

7.41 (7.40–7.46)

0.651

 NMBAs

107 (26.8)

5 (16.7)

43 (24.3)

59 (30.6)

0.177

 RM

61 (15.3)

2 (6.7)

26 (14.7)

33 (17.1)

0.322

 PPV

85 (21.3)

3 (10.0)

29 (16.4)

53 (27.5)

0.011

 ECMO

61 (15.3)

2 (6.7)

23 (13.0)

36 (18.7)

0.142

 HFOV

3 (0.8)

0 (0.0)

1 (0.6)

2 (1.0)

1.000

 High-dose corticosteroidc

157 (29.8)

13 (25.5)

59 (23.6)

85 (37.6)

0.003

  1. IPPV invasive positive pressure ventilation, ICU intensive care unit, SIMV synchronized intermittent mandatory ventilation, PS pressure support, PEEP positive end-expiratory pressure, VT tidal volume, PBW predicted body weight, ABG arterial blood gas, NMBAs neuromuscular blockade, RM lung recruitment manoeuvre, PPV prone position ventilation, EMCO extracorporeal membrane oxygenation, HFOV high-frequency oscillatory ventilation
  2. aPlateau pressure values, driving pressure values, airway resistance values, and respiratory compliance values are limited to patients in whom this value was reported. The number of measured patients is 211 cases. Patients receiving HFOV or ECMO were also excluded
  3. bP value represents comparisons across the ARDS severity categories for each variable
  4. cHigh-dose corticosteroids was defined as doses that were equal to or greater than the equivalent of 1 mg/kg of prednisolone
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Critical Care

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