Table 1 Demographics, clinical Characteristics, and biomarkers by 60-day mortality
Full cohort, n = 919 | Alive at 60 days, n = 658 | Dead by 60 days, n = 261 | p value | |
|---|---|---|---|---|
Age | 49 (38–61) | 47 (37–57) | 57 (41–70) | < 0.001 |
Female sex | 489 (53) | 338 (52) | 151 (58) | 0.076 |
BMI | 27 (23–32) | 28 (24–33) | 26 (22–31) | 0.005 |
Race/ethnicity | ||||
White | 602 (66) | 459 (70) | 143 (55) | < 0.001 |
Black | 193 (21) | 121 (18) | 72 (28) | |
Hispanic | 124 (13) | 78 (12) | 46 (18) | |
Fluid conservative arm | 467 (51) | 342 (52) | 125 (48) | |
Baseline WBC (103/μL) | 11.8 (7.2–17.1) | 12.0 (7.8–17.1) | 10.6 (5.8–17.3) | 0.046 |
Baseline creatinine (mg/dL) | 1.0 (0.7–1.5) | 0.8 (0.7–1.4) | 1.2 (0.9–1.8) | < 0.001 |
Cystatin C (mg/L) | 0.9 (0.7–1.4) | 0.8 (0.6–1.2) | 1.2 (0.9–1.9) | < 0.001 |
AKI# | ||||
Actual | 486 (53) | 306 (47) | 180 (69) | < 0.001 |
Adjusted for fluid balance | 559 (61) | 348 (53) | 211 (81) | < 0.001 |
APACHE III score | 91 (70–117) | 85 (65–104) | 114 (91–133) | < 0.001 |
Primary ARDS risk factor | ||||
Pneumonia | 426 (46) | 303 (46) | 123 (47) | 0.002 |
Sepsis | 218 (24) | 138 (21) | 80 (31) | |
Aspiration | 138 (15) | 104 (16) | 34 (13) | |
Trauma | 71 (8) | 62 (9) | 9 (3) | |
Multiple transfusion | 9 (1) | 7 (1) | 2 (1) | |
Other | 57 (6) | 44 (7) | 13 (5) | |
Hyperinflammatory LCA subphenotype⍺ | 252 (27) | 137 (54) | 115 (46) | < 0.001 |
Comorbidities | ||||
Solid tumor | 14 (2) | 8 (1) | 6 (2) | 0.25 |
Lymphoma | 13 (1) | 4 (1) | 9 (4) | 0.001 |
Leukemia | 20 (3) | 9 (1) | 11 (4) | 0.009 |
Recent surgery | 46 (5) | 37 (6) | 9 (3) | 0.17 |