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Table 1 Comparisons of baseline characteristics between the original cohort and matched cohort

From: Central venous pressure measurement is associated with improved outcomes in septic patients: an analysis of the MIMIC-III database

Covariates Original cohort Matched cohort
CVP No CVP SMD CVP No CVP SMD
N 4516 5759   2174 2174  
Age 69 (56–79) 71 (56–82) 0.079 69 (56–80) 69 (55–81) 0.003
Male (%) 2473/4516 (54.8) 2931/5759 (50.9) 0.078 1131/2174 (52) 1166/2174 (53.6) 0.032
Weight (kg) 79.5 (66.8–95) 75 (62.6–90.2) 0.168 78 (65–94) 77 (64.5–92.5) 0.020
Service unit, n (%)   0.675   0.036
 MICU 1811/4516 (40.1) 3251/5759 (56.5)   1113/2174 (51.2) 1095/2174 (50.4)  
 SICU/TSICU 1213/4516 (26.9) 1451/5759 (25.2)   637/2174 (29.3) 646/2174 (29.7)  
 CCU/CSRU 1492/4516 (33.0) 1057/5759 (18.3)   424/2174 (19.5) 433/2174 (19.9)  
Admission period, n (%)   0.273   0.004
 Before 2008 2854/4516 (63.2) 2868/5759 (49.8)   1307/2174 (60.1) 1311/2174 (60.3)  
 2008–2012 1662/4516 (36.8) 2891/5759 (50.2)   867/2174 (39.9) 863/2174 (39.7)  
Severity of illness
 SOFA score 6 (4–9) 4 (3–6) 0.795 5 (4–7) 5 (3–7) 0.018
 SAPS II score 43 (34–54) 37 (30–46) 0.465 41 (32–49) 40 (32–50) 0.008
Elixhauser comorbidity score 7 (3–12) 7 (2–12) 0.025 7 (3–13) 7 (3–13) 0.013
Interventions, n (%)
 MV use (1st 24 h) 3366/4516 (74.5) 1971/5759 (34.2) 0.885 1189/2174 (54.7) 1203/2174 (55.3) 0.013
 Vasopressor use (1st 24 h) 1406/4516 (31.1) 246/5759 (4.3) 0.752 259/2174 (11.9) 236/2174 (10.9) 0.033
 RRT use (1st 24 h) 238/4516 (5.3) 280/5759 (4.9) 0.019 116/2174 (5.3) 104/2174 (4.8) 0.025
Comorbidities, n (%)
 CHF 996/4516 (22.1) 1296/5759 (22.5) 0.011 535/2174 (24.6) 551/2174 (25.3) 0.002
 AFIB 990/4516 (21.9) 1428/5759 (24.8) 0.068 535/2174 (24.6) 527/2174 (24.2) 0.009
 Chronic renal disease 608/4526 (13.5) 1129/5759 (19.6) 0.166 334/2174 (15.4) 329/2174 (15.1) 0.006
 Liver disease 405/4526 (9.0) 440/5759 (7.6) 0.048 183/2174 (8.4) 183/2174 (8.4) < 0.001
 COPD 908/4526 (20.1) 1272/5759 (22.1) 0.049 477/2174 (21.9) 458/2174 (21.1) 0.021
 Stroke 151/4526 (3.3) 231/5759 (4.0) 0.035 90/2174 (4.1) 83/2174 (3.8) 0.016
 Malignancy 152/4526 (3.4) 201/5759 (3.5) 0.007 73/2174 (7.4) 76/2174 (3.5) 0.008
Vital signs
 MAP (mmHg) 54 (48–60) 58 (51–65) 0.358 55 (49–62) 56 (49–63) 0.013
 Heart rate (bpm) 108 (94–124) 104 (90–119) 0.229 107 (92–122) 106 (93–121) 0.001
 Temperature (°C) 37.7 (37.2–38.3) 37.4 (37–38) 0.260 37.6 (37–38.2) 37.6 (37–38.2) < 0.001
 Respiratory rate (bpm) 28 (24–33) 27 (24–32) 0.102 28 (24–33) 28 (24–32) 0.004
Laboratory tests
 WBC (× 109/L) 15.2 (10.8–20.8) 12.2 (8.7–16.9) 0.253 14.5 (10.2–19.7) 13.1 (9.3–18.2) 0.046
 Hemoglobin (× 1012/L) 9.2 (8–10.5) 10.2 (8.9–11.6) 0.486 9.7 (8.5–11) 9.6 (8.4–11) 0.030
 Platelet (× 109/L) 158 (105–231) 197 (133–270) 0.277 186 (126–257) 187 (118–261) 0.028
 Bicarbonate (mmol/L) 21 (18–23) 23 (19–26) 0.435 21 (18–24) 21 (18–24.8) 0.002
 Bun (mg/dL) 26 (17–43) 26 (17–42) 0.023 27 (17–44) 26 (17–44) 0.004
 Creatinine (mg/dL) 1.3 (0.9–2.1) 1.2 (0.8–1.9) 0.009 1.2 (0.9–2.0) 1.2 (0.8–2.0) 0.010
 Lactate level (mmol/L) 1.9 (1.3–3.1) 1.5 (1.1–2.1) 0.419 1.6 (1.2–2.4) 1.6 (1.1–2.4) 0.024
 pH 7.36 (7.32–7.40) 7.40 (7.36–7.44) 0.535 7.38 (7.33–7.42) 7.38 (7.34–7.43) 0.010
 pO2 (mmHg) 131 (98–178) 109 (84–146) 0.345 117 (90–156) 117 (90–157) 0.040
 pCO2 (mmHg) 39 (35–43) 39 (35–44) 0.132 39 (35–44) 39 (34–44) 0.004
AKI, n (%) 3488/4526 (77.2) 3502/5759 (60.8) 0.361 1507/2174 (69.3) 1489/2174 (68.5) 0.018
  1. MICU medical intensive care, SICU surgical intensive care unit, TSICU trauma surgical intensive care unit, CCU coronary care unit, CSRU cardiac surgery unit, SOFA Sequential Organ Failure Assessment, SAPS II Simplified Acute Physiology Score II, MV mechanical ventilation, RRT renal replacement therapy, CHF congestive heart failure, AFIB atrial fibrillation, COPD chronic obstructive pulmonary disease, MAP mean arterial pressure, WBC white blood cell, PO2 partial pressure of oxygen, PCO2 partial pressure of carbon dioxide, AKI acute kidney injury