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Table 1 Invasive hemodynamic parameters and pressure-volume loops (n = 7/group)

From: Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

 

Sham

CLP-NaCl

CLP-HSL

p value

NaCl vs. sham

HSL vs. NaCl

Pulse pressure (mmHg)

45 [33–48]

22 [19–32]

35 [30–37]

0.006

0.2

Systolic blood pressure (mmHg)

120 ± 19

73 ± 23

88 ± 32

0.006

0.5

Diastolic blood pressure (mmHg)

79 ± 13

50 ± 20

55 ± 29

0.03

0.8

LVEDP (mmHg)

2.3 [1.2–4.4]

2.6 [1.7–4.4]

2.8 [1.9–3.6]

0.9

1

LVESP (mmHg)

114 ± 21

68 ± 22

87 ± 32

0.006

0.3

dP/dtmax (mmHg/s)

7997 ± 2347

2974 ± 988

7110 ± 4582

0.01

0.04

dP/dtmin (mmHg/s)

6492 ± 2045

3079 ± 1503

5489 ± 3564

0.04

0.2

LVESPVR

22 ± 3

21 ± 13

20 ± 3

ns

LVEDPVR

1.0 ± 0.3

3.2 ± 1.2

1.6 ± 0.8

0.0002

0.005

Tau

8.2 ± 3.1

10.6 ± 1.8

9.5 ± 3.6

ns

Osmolality (mosmol/kg)

311 [308–317]

316 [311–323]

318 [317–330]

0.8

0.2

  1. Results are presented as means ± standard deviations or medians with the first and third quartiles according to the normality of the population. Only the results of the post-test are presented as numerical data. In case of a non-significant primary test, the results are presented as “ns”
  2. LVEDP left ventricular end-diastolic pressure, LVESP left ventricular end-systolic pressure, LVEDPVR left ventricular end-diastolic pressure-volume relationship, LVESPVR left ventricular end-systolic pressure-volume relationship, Tau isovolumic relaxation constant, NaCl sodium chloride, HSL hypertonic sodium lactate