Skip to main content

Table 1 Clinical, laboratory and iron profile characteristics of study cohort, total and stratified by severity of hypoxemia

From: Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19

CharacteristicAll patients (n = 30)Severe (n = 10)Non-severe (n = 20) 
Age, median (IQR), years57 (52–64)57 (53–75)57 (52–64)0.949
Males, n (%)17 (57)5 (50)12 (60) 
Females, n (%)13 (33)5 (50)8 (40) 
APACHE II score, median (IQR)13.0 (9.8–15)14.5 (12–20)13 (12–18)0.7512
Clinical Frailty Scale, n (%)
 123 (77)9 (90)14 (70) 
 24 (13)1 (10)3 (15) 
 > 33 (10)03 (15) 
Respiratory support, n (%)
 Non-invasive ventilation18 (60)7 (701)11 (55)0.509
 Invasive ventilation26 (87)10 (100)16 (80)0.378
 Prone position17 (57)10 (100)7 (35)0.004
Advanced cardiovascular support, n (%)4 (13)0 (0)4 (20)0.379
Advanced renal support, n (%)10 (33)5 (50)5 (25)0.271
PaO2/FiO2 ratio, median (IQR)127.5 (87–200.6)82.5 (77–87)190.8 (127.5–277.5)< 0.001
Laboratory data (normal range)
 Haemoglobin (g/L) (120–150), mean (SD)130.4 (20.1)124.7 (16.7)133.2 (21.4)0.280
 White cell count (× 109/L) (4.0–11.0), mean (SD)10.6 (4.8)11.0 (5)10.4 (4.7)0.733
 Lymphocyte count (× 109/L) (1.0–4.0), mean (SD)0.74 (0.4)0.50 (0.2)0.87 (0.42)0.015
 D-dimer (μg/mL) (0–500), median (IQR)3286 (1302–14,227)9505.5 (845–5023)2462 (1453–9850)0.462
 Fibrinogen (g/L) (1.5–4.0), median (IQR)6 (5.5–6.3)6 (5.5–6.3)6.1 (5.5–6.4)0.670
 CRP (mg/L) (0–5), mean (SD)246.2 (100.1)235.8 (101.8)251.4 (101.5)0.69
Iron parameters (normal range)
 Ferritin (mcg/l) (10–200), median (IQR)1476.1 (656.6–2698)903.8 (566.9–2789.2)1566.1 (729–2511.5)0.569
 Serum iron (μmol/L) (11–30), median (IQR)3.6 (2.5–5)2.3 (2.2–2.5)4.3 (3.3–5.2)< 0.001
 Transferrin (g/L) (1.8–3.6), median (IQR)1.5 (1.1–1.8)1.3 (0.8–1.8)1.5 (1.1–1.8)0.784
 Transferrin saturation (%) (16–50), median (IQR)9 (7–13)7 (6–12)12 (8–14)0.122
Pulmonary embolism, n (%)16 (53.5)7 (70)9 (45)0.203
Outcome as of 10 May 2020, n (%)
 Died in ICU6 (20)5 (50)1 (5) 
 Still alive in ICU16 (53)3 (30)13 (65) 
 Discharged alive from ICU8 (27)2 (20)6 (30) 
 ICU length of stay, median (IQR), days8 (4–11)7 (4–9)9 (4–12) 
  1. Abbreviations: APACHEII Acute Physiology and Chronic Health Evaluation II, CRP C-reactive protein, ICU intensive care unit, IQR interquartile range, SD standard deviation