Skip to main content

Table 1 Characteristics of 92 critically ill COVID-19 patients who developed (n = 37, 40%) or not (n = 55, 60%) a thrombotic event during ICU stay (*at the time of analysis (May 6, 2020); data for 91 patients as one patient was lost to follow-up)

From: Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study

 

All patients, n = 92

Patients without thrombotic events, n = 55 (60%)

Patients with thrombotic events, n = 37 (40%)

p

Age (years)

61 [55–70]

61 [55–69]

62 [54–71]

0.89

Male, n (%)

73 (79)

44 (80)

29 (78)

0.55

Body mass index (kg/m2)

30 [26–35]

32 [25–36]

29 [27–34]

0.34

Baseline SOFA

4 [3–7]

4 [2–7]

4 [3–8]

0.6

Baseline SAPS II

31 [21–40]

31 [20–39]

31 [22–44]

0.8

Main comorbidities,n(%)

 Hypertension

59 (64)

36 (65)

23 (62)

0.75

 Diabetes mellitus

35 (38)

22 (40)

13 (35)

0.75

 Cardio-vascular diseases

9 (10)

8 (14)

1 (3)

0.48

 Atrial fibrillation

3 (3)

1 (2)

2 (5)

0.06

 Cerebro-vascular diseases

8 (9)

5 (9)

3 (8)

0.34

 Venous thrombo-embolism

5 (5)

3 (5)

2 (5)

0.89

 Chronic respiratory diseases

18 (20)

11 (20)

7 (19)

0.99

 Chronic renal failure

7 (8)

7 (13)

0

0.03

Laboratory measurements at ICU admission

 Fibrinogen (g/L)

7.8 [6.1–8.8]

7.5 [6.0–8.6]

7.9 [6.3–9]

0.45

 D-dimers (μg/mL)

2.4 [1.7–7.9]

2.2 [1.2–5.9]

4.4 [1.8–2]

0.03

 Prothrombin time (%)

86 [76–96]

92 [80–100]

79 [68–90]

< 0.001

 Platelets (G/L)

227 [182–307]

213 [170–302]

235 [198–340]

0.17

Thromboprophylaxis strategy

 Usual (prophylactic) anticoagulation

43 (47)

26 (47)

17 (46)

0.90

 Full-dose (therapeutic) anticoagulation

49 (53)

29 (53)

20 (54)

0.90

Outcome in ICU,n(%)

 Invasive mechanical ventilation

82 (89)

46 (84)

36 (97)

0.04

 Prone positioning

55 (60)

32 (58)

23 (62)

0.70

 Vasopressor support

57 (62)

31 (56)

26 (70)

0.18

 Renal replacement therapy

22 (24)

11 (20)

11 (30)

0.28

 ICU mortality*

38 (41)

20 (36)

18 (49)

0.24

 Still hospitalized in ICU*

25 (27)

13 (24)

12 (32)

0.35

 Discharged to the wards*

28 (30)

21 (38)

7 (19)

0.05

  1. Continuous variables were reported as median [Interquartile range] (IQR) and compared between groups using the Mann-Whitney test. Categorical variables were reported as numbers and percentages and compared using χ2 test or Fisher’s exact test, as appropriate. A p value < 0.05 was considered significant