Fig. 1
From: Cyclosporine A: a valid candidate to treat COVID-19 patients with acute respiratory failure?
Schematic overview of the presumed protective effects of cyclosporine A in COVID-19-induced acute respiratory failure. Cyclosporine A (CsA), binding to cyclophilin A (Cyp-A), prevents the translocation of nuclear factor of activated T cells (NF-AT) into the nucleus (left box) and blocks viral replication (middle box) and thus transcription of pro-inflammatory cytokines (e.g., interleukin-2). CsA, binding to cyclophilin D (Cyp-D), also prevents mitochondrial permeability transition pore (mPTP) opening-induced injury and thus cell death/dysfunction (right box). The red color is used to indicate the effects of CsA