From: The gut microbiome’s role in the development, maintenance, and outcomes of sepsis
Author, year [citation] | Location | Patient age, sex, comorbidity | ICU complications | Sepsis etiology | Gut microbiome changes with FMT | Outcome |
---|---|---|---|---|---|---|
Li, 2014 [80] | China | 29F, UC | Bacteremia, shock | Unclear; prolonged diarrhea | • Pre: few anaerobes, abundant pathogens including Enterobacter | Clinical improvement |
• Post: shifted to donor stool; increased Bacteroides and Firmicutes | ||||||
Li, 2015 [43] | China | 44F, s/p proximal gastrectomy and vagotomy for NET | Shock, respiratory failure (V-V ECMO), AKI (CRRT) | Unclear; prolonged diarrhea | • Pre: few anaerobes, abundant pathogens including Enterobacter and Klebsiella | Clinical improvement |
• Post: increased Firmicutes; decreased pathobionts | ||||||
Wei, 2016 [82] | China | 65M, hemorrhagic CVA | Shock, respiratory failure, bacteremia | Unclear; prolonged diarrhea | • Pre: different from donor | Clinical improvement |
• Post: increased Firmicutes, Bacteroides | ||||||
Wei, 2016 [82] | China | 84M, ischemic CVA | AKI (CRRT) | Unclear; prolonged diarrhea | • Pre: different from donor | Clinical improvement |
• Post: increased Firmicutes, decreased pathobionts | ||||||
Gopalsamy, 2018 [81] | USA | 57M, TBI | MDRO infection, respiratory failure | Pneumonia | Not studied | Death |