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Table 1 Baseline characteristics and clinical outcomes in the derivation cohort (FORECAST cohort)

From: Significance of body temperature in elderly patients with sepsis

 

Non-elderly (< 75 years) (n = 628)

Elderly (≥ 75 years) (n = 520)

P value

Characteristics

 Age, years

65 (55–70)

82 (78–86)

< 0.0001

 Male sex, n (%)

405 (64.5)

288 (55.4)

0.0017

 Suspected site of infection, n (%)

  Lung

193 (30.7)

164 (31.5)

0.77

  Intra-abdominal

150 (23.9)

145 (27.9)

0.12

  Urinary tract

102 (16.2)

116 (22.3)

0.0091

  Soft tissue

79 (12.6)

35 (6.7)

0.0010

  Othersa

104 (16.6)

60 (11.5)

0.015

 Septic shock, n (%)

387 (61.6)

331 (63.7)

0.48

 Body mass index

22.5 (19.3–25.2)

20.8 (18.6–23.9)

< 0.0001

 Chronic steroid use, n (%)

86 (13.7)

55 (10.6)

0.11

 Comorbidity, n (%)

  Diabetes mellitus

155 (24.7)

107 (20.6)

0.099

  Stroke

55 (8.8)

78 (15.0)

0.0010

  Malignancy

101 (16.1)

77 (14.8)

0.55

  Heart failure

49 (7.8)

74 (14.2)

0.0005

  Chronic kidney disease

39 (6.2)

41 (7.9)

0.27

  Liver disease

43 (6.8)

25 (4.8)

0.15

  Chronic lung disease

39 (6.2)

41 (7.9)

0.27

 Charlson comorbidity index

1 (0–2)

1 (0–2)

0.014

 SOFA score

9 (6–11)

9 (6–11)

0.73

 APACHE II score

22 (16–29)

23 (18–30)

0.085

 Vital signs on day 1b

  Body temperature, °C

38.0 (36.8–39.0)

37.6 (36.7–38.5)

0.0003

  Heart rate, beats/min

114 (96–133)

108 (91–123)

< 0.0001

  Mean arterial pressure, mmHg

63 (53–78)

63 (52–78)

0.65

  Systolic blood pressure, mmHg

86 (72–110)

90 (72–110)

0.38

  Respiratory rate, breath/min

25 (20–32)

25 (20–32)

0.63

Outcome

 28-day in-hospital mortality, n (%)

90 (14.3)

100 (19.2)

0.026

 90-day in-hospital mortality, n (%)

123 (19.6)

130 (25.0)

0.028

  1. Median (interquartile range)
  2. SOFA sequential organ failure assessment, APACHE acute physiology and chronic health evaluation
  3. aIncluding central nervous system, catheter-related, osteoarticular, endocardium, wound, implant device-related, and undifferentiated infection
  4. bMost abnormal value corresponding to the APACHE II score
  5. P values were calculated using Pearson’s chi-square test and Mann-Whitney U test