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Table 3 Perioperative changes in sublingual microvascular flow index (MFI) per study

From: Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review

Study

n

Technique

Study groups

Pre-CPB

CPB

Post-CPB

Induction

Onset of CPB

Late phase of CPB

Post-CPB

ICU

24 h after surgery

den Uil et al. [29]

25

SDF

CS with CPB

~ MFI

~ MFI

–

~ MFI

~ MFI

–

  

CS with CPB (vessels 25–50 μm)

~ MFI

↓ MFI

–

~ MFI

~ MFI

–

  

CS with CPB (vessels 50–100 μm)

~ MFI

~ MFI

–

~ MFI

~ MFI

–

Holmgaard et al. [21]

30

SDF

CABG with HMAP

–

~ MFI

–

~ MFI

–

–

  

CABG with LMAP

–

~ MFI

–

~ MFI

–

–

Koning et al. [24]

33

SDF

CABG non pulsatile CPB

–

~ MFI

↓ MFI

↓ MFI

↓ MFI

–

  

CABG pulsatile CPB

–

~ MFI

~ MFI

~ MFI

~ MFI

–

Koning et al. [31]

13

SDF

CABG

–

~ MFI

~ MFI

~ MFI

↓ MFI

–

Koning et al. [30]

18

SDF

CABG

–

~ MFI

–

 

↓ MFI

–

Mohamed et al. [22]

70

SDF

CABG regular anesthesia

–

↓ MFI

–

↓ MFI

–

–

  

CABG dexmed anesthesia

–

↓ MFI

–

~ MFI

–

–

Özarslan et al. [20]

30

OPS

CABG sevoflurane anesthesia

~ MFI

~ MFI

–

~ MFI

–

~ MFI

  

CABG isoflurane anesthesia

~ MFI

↓ MFI

–

~ MFI

–

~ MFI

  

CABG desflurane anesthesia

~ MFI

~ MFI

–

~ MFI

–

~ MFI

Prestes et al. [23]

22

SDF

Cardiac surgery with CPB

–

~ MFI

↓ MFI

↑ MFI

–

–

Yuruk et al. [27]

20

SDF

CABG

–

~ MFI

–

~ MFI

–

–

  

CABG with MECC

–

~ MFI

–

~ MFI

–

–

  1. A downward facing arrow (↓) represents a significant decrease compared to baseline measurement. An upward facing arrow (↑) represents a significant increase compare to baseline measurement. ~ represents no significant change compared to baseline value. MFI microvascular flow index, CPB cardiopulmonary bypass, SDF side-stream dark field imaging, OPS orthogonal polarization spectral imaging, n number of participants, h hours, CS cardiac surgery, CABG coronary artery bypass grafting, MECC minimal extracorporeal circulation, LMAP low mean arterial pressure group, HMAP high mean arterial pressure group