Fig. 1

Changes in oxygenation parameters in the first 48 h of angiotensin II infusion. Data are median and quartile 25% to quartile 75%. The changes in the parameters over time were assessed with a mixed–effect quantile model based on the asymmetric Laplace distribution (τ = 0.50, a median regression), taking into account repeated measurements and considering the time of measurements (as a continuous variable) as fixed effect. The p value in the graphs represents the changes over this time. In all models, only values at and after the start of the infusion drug were taken into account, and the values before the start were used only for graphic purpose. All results were confirmed after bootstrapping with 10,000 replications. All analyses were conducted in R (R Foundation), version 3.6.3