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Table 2 Baseline predisposition characteristics of overall cohort and five major site subgroups. BMI body mass index, ESRD end-stage renal disease

From: Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study

 Overall, n = 316Abdominal, n = 140 (44%)Pulmonary, n = 59 (19%)S/ST, n = 56 (18%)GU, n = 40 (12%)Vascular, n = 21 (7%)p value
Male, n (%)173 (55)68 (49)42 (71)28 (50)20 (50)15 (71)0.02
Age in years, median (25th, 75th)62 (50,70)63 (50,71)62 (54,68)56 (44,64)61 (51,73)69 (58,73)0.03
Age ≥ 65 years, n (%)125 (40)60 (43)22 (37)12 (21)18 (45)13 (62)< 0.01
Race, n (%)      0.39
 Caucasian (White)283 (90)127 (91)56 (95)47 (84)34 (85)19 (90) 
 African American28 (9)10 (7)3 (5)8 (14)6 (15)1 (5) 
 Other5 (1)3 (2)0 (0)1 (2)0 (0)1 (5) 
Hispanic ethnicity8 (3)3 (2)1 (2)2 (4)1 (3)1 (4) 
BMI, median (25th, 75th)29 (25,37)28 (24,34)29 (24,33)35 (28,43)34 (26,39)28 (25,33)< 0.01
Number of comorbidities
 165 (21)28 (20)14 (24)14 (25)7 (18)2 (10)0.61
 265 (21)34 (24)12 (20)9 (16)7 (18)3 (14)0.69
 ≥ 3134 (42)57 (41)23 (39)23 (41)17 (43)14 (67)0.25
Charlson comorbidity index, median (25th, 75th)3 (1,5)3 (1,5)3 (1,4)2 (1,4)3 (1,5)4 (3,7)0.07
Type of comorbidities
 Hypertension195 (62)86 (61)41 (70)28 (50)24 (60)16 (77)0.16
 Diabetes109 (34)44 (31)14 (24)30 (54)14 (35)7 (33)0.02
 Coronary artery disease80 (25)32 (23)16 (27)11 (20)10 (25)11 (52)0.07
 Chronic lung disease62 (20)32 (23)17 (29)6 (11)1 (2)6 (29)< 0.01
 Morbid obesity56 (18)22 (16)7 (12)17 (30)8 (20)2 (10)0.08
 Chronic renal disease44 (14)17 (12)7 (12)9 (16)6 (15)5 (24)0.60
  ESRD8 (3)3 (2)2 (3)1 (2)0 (0)2 (10)0.25
 Atrial fibrillation38 (12)17 (12)4 (7)8 (14)5 (12)4 (19)0.54
 Peripheral artery disease38 (12)12 (9)6 (10)5 (9)4 (10)11 (53)< 0.01
 Heart failure37 (12)13 (9)8 (14)8 (14)3 (8)5 (24)0.28
 Prior Stroke24 (8)15 (11)5 (8)2 (4)2 (5)0 (0)0.33
 Substance abuse21 (7)11 (8)5 (8)3 (5)0 (0)2 (10)0.32
 Dementia7 (2)3 (2)2 (3)0 (0)1 (2)1 (5)0.49
 Liver cirrhosis6 (2)2 (1)2 (3)1 (2)1 (2)0 (0)0.85
 History of cancer, n (%)82 (26)46 (33)14 (24)9 (16)10 (25)3 (14)0.10
 Active cancer, n (%)47 (15)30 (21)9 (15)3 (5)5 (12)0 (0)< 0.01
Reason for hospital admission, n (%)
 Active infection188 (60)93 (66)4 (7)51 (91)23 (58)17 (81)< 0.01
 Elective surgery64 (20)29 (21)18 (31)3 (5)12 (30)2 (9)< 0.01
 Trauma33 (10)5 (4)25 (42)1 (2)1 (2)1 (5)< 0.01
 Chronic health condition31 (10)13 (9)12 (20)1 (2)4 (10)1 (5)0.02
Inter-facility hospital transfer, n (%)129 (40.8)64 (45.7)19 (32.2)21 (37.5)6 (15)19 (90.5)< 0.01