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Table 2 Baseline predisposition characteristics of overall cohort and five major site subgroups. BMI body mass index, ESRD end-stage renal disease

From: Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study

 

Overall, n = 316

Abdominal, n = 140 (44%)

Pulmonary, n = 59 (19%)

S/ST, n = 56 (18%)

GU, n = 40 (12%)

Vascular, n = 21 (7%)

p value

Male, n (%)

173 (55)

68 (49)

42 (71)

28 (50)

20 (50)

15 (71)

0.02

Age in years, median (25th, 75th)

62 (50,70)

63 (50,71)

62 (54,68)

56 (44,64)

61 (51,73)

69 (58,73)

0.03

Age ≥ 65 years, n (%)

125 (40)

60 (43)

22 (37)

12 (21)

18 (45)

13 (62)

< 0.01

Race, n (%)

      

0.39

 Caucasian (White)

283 (90)

127 (91)

56 (95)

47 (84)

34 (85)

19 (90)

 

 African American

28 (9)

10 (7)

3 (5)

8 (14)

6 (15)

1 (5)

 

 Other

5 (1)

3 (2)

0 (0)

1 (2)

0 (0)

1 (5)

 

Hispanic ethnicity

8 (3)

3 (2)

1 (2)

2 (4)

1 (3)

1 (4)

 

BMI, median (25th, 75th)

29 (25,37)

28 (24,34)

29 (24,33)

35 (28,43)

34 (26,39)

28 (25,33)

< 0.01

Number of comorbidities

 1

65 (21)

28 (20)

14 (24)

14 (25)

7 (18)

2 (10)

0.61

 2

65 (21)

34 (24)

12 (20)

9 (16)

7 (18)

3 (14)

0.69

 ≥ 3

134 (42)

57 (41)

23 (39)

23 (41)

17 (43)

14 (67)

0.25

Charlson comorbidity index, median (25th, 75th)

3 (1,5)

3 (1,5)

3 (1,4)

2 (1,4)

3 (1,5)

4 (3,7)

0.07

Type of comorbidities

 Hypertension

195 (62)

86 (61)

41 (70)

28 (50)

24 (60)

16 (77)

0.16

 Diabetes

109 (34)

44 (31)

14 (24)

30 (54)

14 (35)

7 (33)

0.02

 Coronary artery disease

80 (25)

32 (23)

16 (27)

11 (20)

10 (25)

11 (52)

0.07

 Chronic lung disease

62 (20)

32 (23)

17 (29)

6 (11)

1 (2)

6 (29)

< 0.01

 Morbid obesity

56 (18)

22 (16)

7 (12)

17 (30)

8 (20)

2 (10)

0.08

 Chronic renal disease

44 (14)

17 (12)

7 (12)

9 (16)

6 (15)

5 (24)

0.60

  ESRD

8 (3)

3 (2)

2 (3)

1 (2)

0 (0)

2 (10)

0.25

 Atrial fibrillation

38 (12)

17 (12)

4 (7)

8 (14)

5 (12)

4 (19)

0.54

 Peripheral artery disease

38 (12)

12 (9)

6 (10)

5 (9)

4 (10)

11 (53)

< 0.01

 Heart failure

37 (12)

13 (9)

8 (14)

8 (14)

3 (8)

5 (24)

0.28

 Prior Stroke

24 (8)

15 (11)

5 (8)

2 (4)

2 (5)

0 (0)

0.33

 Substance abuse

21 (7)

11 (8)

5 (8)

3 (5)

0 (0)

2 (10)

0.32

 Dementia

7 (2)

3 (2)

2 (3)

0 (0)

1 (2)

1 (5)

0.49

 Liver cirrhosis

6 (2)

2 (1)

2 (3)

1 (2)

1 (2)

0 (0)

0.85

 History of cancer, n (%)

82 (26)

46 (33)

14 (24)

9 (16)

10 (25)

3 (14)

0.10

 Active cancer, n (%)

47 (15)

30 (21)

9 (15)

3 (5)

5 (12)

0 (0)

< 0.01

Reason for hospital admission, n (%)

 Active infection

188 (60)

93 (66)

4 (7)

51 (91)

23 (58)

17 (81)

< 0.01

 Elective surgery

64 (20)

29 (21)

18 (31)

3 (5)

12 (30)

2 (9)

< 0.01

 Trauma

33 (10)

5 (4)

25 (42)

1 (2)

1 (2)

1 (5)

< 0.01

 Chronic health condition

31 (10)

13 (9)

12 (20)

1 (2)

4 (10)

1 (5)

0.02

Inter-facility hospital transfer, n (%)

129 (40.8)

64 (45.7)

19 (32.2)

21 (37.5)

6 (15)

19 (90.5)

< 0.01