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Table 2 Development of the GSEM model

From: Structural equation modeling the “control of gut overgrowth” in the prevention of ICU-acquired Gram-negative infection

 Model 1Model 2Model 3Model 4Model 5Model 7Model 6
Fig S8Fig S9Fig S10Fig S11Fig S12Fig S14Fig S1395% CI
Factora,b,c,d,e,f,g,h,i
b_Ps_n
Pseudomonas gut overgrowth1111111Constrained
ppap  1.11**0.97**0.97**1.00**0.95**0.27 to 1.61
_cons− 5.18***− 5.19***− 5.38***− 6.00***− 6.00***− 6.05***− 6.05***− 6.6 to − 5.4
b_Ac_n
Acinetobacter GO1111111Constrained
ppap  0.60.460.480.440.47− 0.51 to 4639
_cons− 6.74***− 6.74***− 6.83***− 7.38***− 7.44***− 7.47***− 7.47***− 8.0 to − 7.0
v_Ps_n
Pseudomonas gut overgrowth0.67***0.67***0.71***0.80***0.80***0.81***0.81***0.51 to 1.09
mvp900.55*0.54*0.49*0.430.430.48*0.49*0.03 to 0.92
non_D− 0.37*− 0.58***− 0.61***− 0.60***− 0.60***− 0.54***− 0.54***− 0.79 to − 0.31
_cons− 3.63***− 3.63***− 3.56***− 4.17***− 4.17***− 4.24***−4.25***− 4.7 to − 3.7
v_Ac_n
Acinetobacter gut overgrowth0.73***0.73***0.74***0.83***0.83***0.83***0.83***+ 0.66 to 1.01
mvp900.79*0.79*0.730.710.690.710.7− 0.12 to 1.55
non_D− 0.35− 0.31− 0.33− 0.27− 0.21− 0.17− 0.17− 0.56 to 0.23
_cons− 5.13***− 5.13***− 5.06***− 5.79***− 5.85***− 5.88***− 5.87***− 6.8 to −4.9
Pseudomonas gut overgrowth        
TAP− 0.65**− 0.65**− 0.67***− 0.68***− 0.68***− 0.47*− 0.57***− 0.91 to − 0.29
a_S− 1.34***− 1.33***− 1.20***− 1.01***− 1.00***− 0.94***− 0.93***− 1.46 to − 0.46
eap     − 0.21  
ppap0.270.27      
non_D−0.33       
los7   1.03***1.03***0.96***0.97***0.53 to 1.45
trauma50    0.040.030.02− 0.33 to 0.36
CC     0.56**0.56**0.08 to 1.10
Acinetobacter gut overgrowth
TAP− 0.25− 0.25− 0.27− 0.27− 0.5− 0.58− 0.43− 1.04 to 0.15
a_S− 1.26*− 1.27*− 1.21*− 1.04*− 0.85− 0.8− 0.82− 1.83 to 0.19
eap     0.25  
ppap0.10.1      
non_D0.06       
los7   1.15***1.01***0.99***0.98***0.41 to 1.54
trauma50    1.09***1.04***1.04***0.47 to 1.62
CC     0.420.42− 0.22 to 1.22
Error terms
var(e.Ps_GO)1.32*1.32*1.17**0.76**0.76**0.71**0.72**0.36 to 1.47
var(e.Ac_GO)2.66***2.66***2.56***1.92***1.62***1.60***1.60***1.01 to 2.48
Model fitj
AIC3345.943344.153329.293274.573261.553259.13255.53 
N22202022242826 
Groups (n)334334334334334334334 
Clusters (n)213213213213213213213 
  1. *p < 0.05; **p < 0.01; ***p < 0.001
  2. av_ps_n is the count of Pseudomonas VAP; v_ac_n is the count of Acinetobacter VAP; b_ps_n is the count of Pseudomonas bacteremia; and b_ac_n is the count of Acinetobacter bacteremia
  3. bPPAP is the group-wide use of protocolized parenteral antibiotic prophylaxis; TAP is topical antibiotic prophylaxis; eap is enteral antibiotic prophylaxis
  4. ce.Ac_GO is the error term for the Acinetobacter gut overgrowth latent variable
  5. de.Ps_GO is the error term for the Pseudomonas gut overgrowth latent variable
  6. eMVP90 is the use of mechanical ventilation by more than 90% of the group
  7. fLOS7 is a mean or median length of ICU stay for the group of 7 days or greater
  8. gTrauma ICU arbitrarily defined as an ICU for which > 50% of admissions were for trauma
  9. hCC is the concurrency of control groups with an intervention group receiving TAP
  10. iLess than 90% of the group receiving prolonged mechanical ventilation.
  11. jModel fit; AIC is Akaike’s information criteria. This indicates model fit taking into account the statistical goodness of fit and the number of parameters in the model. Lower values of AIC indicate a better model fit. N is the number of parameters in the model