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Table 3 Clinical outcomes

From: Physiologic approach to diuresis in de-resuscitation phase in intensive care

Parameter

Historical cohort (n = 273)

Intervention cohort (n = 91)

p value

Clinical outcomes

 72 h fluid balance (mL)a

265 (− 2283–3025)

− 2257 (− 5676–920)

< 0.0001

 48 h fluid balance (mL)a

309 (− 1267–2434)

− 1799(− 3884–1092)

< 0.0001

 24 h fluid balance (mL)a

101 (− 963–1622)

− 692 (− 1833–697)

0.0002

 Ventilator-free days (days)a

19 (10–22)

20 (15–23)

0.098

 Overall adverse eventb,e

74 (27.1)

37 (40.6)

0.015

 Ventilator days (days)a

8 (5–13)

5 (5–12)

0.441

 Furosemide to extubation (hours)a

70 (24–147)

58 (23–122)

0.282

 Re-intubation rateb

57 (20.8)

17 (18.6)

0.652

 ICU-free days (days)a

17 (7–21)

19 (13–22)

0.030

 ICU days (days)a

8.6 (6.2–13.5)

8.1 (5.9–12.8)

0.513

 In-hospital mortalityc

44 (16.1)

5 (5.5)

0.008

Safety outcomes

 Bolus administration after furosemidec

4 (1.5)

0 (0)

0.576

 Vasopressor administration after furosemideb

65 (23.8)

19 (20.9)

0.566

 Tachyarrhythmiab

50 (18.3)

15 (16.4)

0.693

 In-hospital mortalityc

44 (16.1)

5 (5.5)

0.008

 RRT receipt in ICUc

17 (6.2)

0 (0)

< 0.0001

 RRT dependence at dischargec

14 (5.1)

0 (0)

0.025

 Acute kidney injuryf

62 (22.7)

22 (24.2)

0.775

 Hypokalemiac

0

3 (3.3)

0.015

 Hypernatremiab

19 (6.9)

19 (20.9)

0.001

 Metabolic alkalosisc

3 (1.1)

1 (1.1)

1.000

  1. aWilcoxon rank sum, median (interquartile range)
  2. bChi-square test, number (percentage)
  3. cFisher’s exact, number (percentage)
  4. dStudent’s t test, average (standard deviation)
  5. eOverall adverse event: serum creatinine rise, hypokalemia, hypernatremia, or metabolic alkalosis
  6. fAcute kidney injury: serum creatinine 1.5 times baseline serum creatinine, serum creatinine increase of at least 0.3 mg/dL