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Table 2 Ventilator settings and respiratory targets utilized in the three clinical scenarios

From: VENTILatOry strategies in patients with severe traumatic brain injury: the VENTILO Survey of the European Society of Intensive Care Medicine (ESICM)

PaO2/FiO2 TV (ml/kg PBW) Highest PEEP
no-IH
(cmH2O)
Highest PEEP
IH
(cmH2O)
PaCO2
no-IH
(mmHg)
PaCO2
IH
(mmHg)
PaO2(mmHg) SpO2(%)
1) > 300 6–8
[433(72%)]
4–6
[136(23%)]
8–10
[21(3%)]
other
[11(2%)]
15
[182(30%)]
10
[158(26%)]
8
[94(15%)]
5
[69(13%)]
other
[98(16%)]
5
[163(27%)]
10
[155(26%)]
8
[135(23%)]
15
[52(8%)]
other
[96(16%)]
36–40
[308(51%)]
41–45
[105(18%)]
any PaCO2*
[93(16%)]
30–35
[54(9%)]
46–55
[16(2%)]
other
[25(4%)]
36–40
[260(43%)]
30–35
[249(41%)]
41–45
[42(8%)]
46–55
[8(1%)]
any PaCO2*
[7(1%)]
other
[35(6%)]
81–100
[345(57%)]
55–80
[101(17%)]
101–120
[93(15%)]
nmt**
[44(7%)]
> 120
[18(4%)]
> 95
[311(52%)]
92–94
[257(43%)]
88–91
[33(5%)]
2) 150–300 6–8
[331(61%)]
4–6
[192(36)]
8–10
[3(1%)]
other
[10(2%)]
15 [218(41%)]
10 [136(25%)]
8 [71(13%)]
5 [23(5%)]
other [88(16%)]
10
[171(32%)]
8
[131(24%)]
5
[103(19%)]
15
[54(11%)]
other
[77(14%)]
36–40
[250(47%)]
41–45
[110(21%)]
any PaCO2*
[91(19%)]
46–55
[35(6%)]
30–35
[34(6%)]
other
[20(4%)]
36–40
[262(49%)]
30–35
[176[33%)]
41–45
[54(9%)]
any PaCO2*
[10(2%)]
46–55
[4(1%)]
other
[30(6%)]
81–100
[283(53%)]
55–80
[115(21%)]
101–120
[84(16%)]
nmt**
[35(6%)]
>  120
[19(4%)]
92–94
[258(48%)]
>  95
[228(43%)]
88–91
[50(9%)]
3) < 150 4–6
[252(53%)]
6–8
[203(42%)]
8–10
[9(2%)]
other
[16(3%)]
15 [239(50%)]
10 [95(20%)]
8 [37(7%)]
5 [14(3%)]
other [96(20%)]
10
[158(33%)]
8
[94(20%)]
15
[91(19%)]
5
[55(11%)]
other
[83(17%)]
36–40
[175(37%)]
41–45
[118(25%)]
any PaCO2*
[87(16%)]
46–55
[48(10%)]
30–35
[29(7%)]
other
[19(5%)]
36–40
[224(47%)]
30–35
[129[26%)]
41–45
[75(16%)]
any PaCO2*
[15(3%)]
46–55
[9(2%)]
other
[29(6%)]
81–100
[218(45%)]
55–80
[151(32%)]
101–120
[61(13%)]
nmt**
[36(7%)]
> 120
[14(3%)]
92–94
[227(47%)]
> 95
[148(31%)]
88–91
[106(22%)]
  1. *If arterial pH is in range
  2. **Adjusted to
  3. Abbreviations: TV tidal volume, PEEP positive end-expiratory pressure, PaCO2 partial pressure of arterial carbon dioxide, PaO2 partial pressure of arterial oxygen, SpO2 arterial blood oxygen saturation, IH intracranial hypertension, PBW predicted body weight, nmt neuromonitoring