Acyclovir for ventilator-associated pneumonia refractory to antibiotics and with high viral herpes simplex load: we are not sure

Table 2 Renal function of antivirally treated patients (n = 59)

Antiviral treatment	Daily dose of aciclovir (mg)	Daily urine volume (ml)	Estimated GFR <60 ml/min/1.73m2	Serum creatine (mg/dl)
Day 0	1000 [750 -1500]; n = 58	2300 [1550-3175]; n = 59	41.1 [21.1-50.1]; n = 19	1.01 [0.66-1.23]; n = 55
Day 1	2250 [1500-2250]; n = 58	2700 [1800-3600]; n = 59	40.5 [22.4-47.3]; n = 22	0.93 [0.67-1.39]; n = 57
Day 2	2100 [1400-2250]; n = 57	2404 [1435-3438]; n = 58	44.7 [27.8-51.7]; n = 25	1.04 [0.68-1.35]; n = 57
Day 3	1850 [1150-2250]; n = 52	2620 [1390-3813]; n = 52	41.6 [31.7-47.4]; n = 22	0.96 [0.65-1.50]; n = 51
Day 4	2000 [1000-2250]; n = 45	2900 [2000-3350]; n = 45	40.3 [20.3-45.2]; n = 17	0.97 [0.69-1.42]; n = 44
Day 5	2000 [1260-2250]; n = 36	3220 [2075-4293]; n = 36	41.3 [38.4-50.1]; n = 17	1.04 [0.67-1.46]; n = 37
Day 6	2250 [1500-2250]; n = 34	2725 [1928-3868]; n = 34	42.0 [39.5-48.0]; n = 14	0.97 [0.66-1.44]; n = 33
Day 7	2125 [1500-2250]; n = 30	2800 [2075-4075]; n = 30	42.3 [37.8-48.8]; n = 12	0.84 [0.62-1.35]; n = 31

Data from clinical charts and laboratory information system is restricted to its availibility (not for patients who died) and to the phase of antiviral treatment. One gangciclovir treated patient was excluded for calculation of the daily acyclovir dose. The different variables are shown as medians, followed by the interquartile ranges in brackets [IQR] and finally added by the number (n) of values availibe. Estimated glomerular filtration rate (GFR) was calculated by MDRD Equation and only listed if the estimated GFR was below 60 ml/min/1.73m2

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